PENGARUH PENYIMPANAN TERHADAP KADAR IBUPROFEN DALAM SEDIAAN SUSPENSI SECARA SPEKTROFOTOMETRI UV-VIS

Santoso, Farra Aliefia (2021) PENGARUH PENYIMPANAN TERHADAP KADAR IBUPROFEN DALAM SEDIAAN SUSPENSI SECARA SPEKTROFOTOMETRI UV-VIS. Karya Tulis Ilmiah thesis, Universitas Setia Budi.

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Abstract

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID). One of the uses of ibuprofen oral suspension is as a fever-reducing drug. Its use only to relieve symptoms causes ibuprofen suspensions to be often kept in stock for reuse if needed. This aims of this study were to determine the suitability of ibuprofen levels in the sample with the requirements for levels of ibuprofen oral suspension in the Indonesian Pharmacopoeia Edition VI of 2020 and to determine the effect of drug storage on the levels of ibuprofen oral suspension. The analytical method used to determine the level of ibuprofen in the oral suspension sample was UV-Vis spectrophotometry. Samples were conditioned to 2 storage areas, namely room storage (25-30ºC) and refrigerator storage (2-8ºC), then the levels were analyzed on the 0, 7 and 14 days. The sample was prepared with 0.1 N NaOH solvent and the absorbance was measured at a maximum wavelength of 222 nm within an operating time of 4-6 minutes. Validation of analytical methods was also carried out including linearity, accuracy, precision, limit of detection (LOD) and limit of quantitation (LOQ). The results of the study showed that the levels of samples of oral suspension of ibuprofen brands A, B and C before being treated all met the requirements for drug levels in the Indonesian Pharmacopoeia Edition VI of 2020, which were between 90% - 110%. Samples stored at refrigerator temperature are known to have decreased levels that are not in accordance with the provisions in the Indonesian Pharmacopoeia Edition VI. It is known that storage time and temperature affect ibuprofen levels in oral suspension preparations. Keywords : ibuprofen suspension, storage temperature, storage time, UV-Vis spectrophotometry

Item Type:	Thesis (Karya Tulis Ilmiah)
Uncontrolled Keywords:	ibuprofen suspension, storage temperature, storage time, UV-Vis spectrophotometry
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi D3 Analis Farmasi dan Makanan
Depositing User:	Tifany Nur Arfiana
Date Deposited:	16 Aug 2022 06:52
Last Modified:	16 Aug 2022 06:52
URI:	http://repo.setiabudi.ac.id/id/eprint/5133

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