FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN OBAT KUMUR EKSTRAK ETANOL BUAH MURBEI (Morus alba L.) TERHADAP BAKTERI Streptococcus mutans ATCC 25175

NINGSI, AMISAH DIA (2022) FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN OBAT KUMUR EKSTRAK ETANOL BUAH MURBEI (Morus alba L.) TERHADAP BAKTERI Streptococcus mutans ATCC 25175. Skripsi thesis, Universitas Setia Budi.

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Abstract

Mouthwash is an oral cleaning solution that is used to kill microorganisms, preventing the formation of plaque and caries on the teeth. The main cause of dental caries is the bacterium Streptococcus mutans. Mulberry fruit has potential as an antibacterial against Streptococcus mutans because it contains alkaloids, flavonoids, phenolics, and terpenoids. The purpose of this study was to evaluate the stability of the mouthwash preparation of mulberry fruit ethanol extract and to test its antibacterial activity against the bacterium Streptococcus mutans ATCC 25175. This study used mulberry fruit extract which was made by maceration, then the mulberry fruit extract was made into a mouthwash formulation with a concentration variation of 3.125%; 6.25%; 12.5%; and 0%, as well as using the market mouthwash preparation "L" (positive control). Evaluation of the preparation includes organoleptic, homogeneity, specific gravity, pH, viscosity, and stability of the preparation. The mouthwash preparation was tested with the bacterium Streptococcus mutans ATCC 25175 using the well diffusion method by observing the inhibition zone formed. The test data were analyzed statistically using the Shapirow-Wilk test followed by the one way ANOVA test. The results showed that the mouthwash preparations of mulberry fruit extract in all formulas had good organoleptic physical qualities, viscosity, and stability, while in testing the physical quality of pH did not meet the pH requirements of mouthwash preparations due to the influence of mulberry fruit extract (Morus alba L.) . The results of the antibacterial activity test against Streptococcus mutans ATCC 25175 with a concentration variation of 3.125%; 6.25%; and 12.5% had inhibition zone diameters of 10 mm, respectively; 14.83 mm; and 19.5 mm. Based on the results of antibacterial testing, formula 2 is effective because it has the same inhibitory power as the positive control. Keywords : antibacterial, mulberry fruit extract, mouthwash, Streptococcus mutans ATCC 25175

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	ntibacterial, mulberry fruit extract, mouthwash, Streptococcus mutans ATCC 25175
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	29 Sep 2022 04:37
Last Modified:	29 Sep 2022 04:37
URI:	http://repo.setiabudi.ac.id/id/eprint/5251

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