UJI AKTIVITAS DIURETIK TABLET EFFERVESCENT EKSTRAK BIJI PEPAYA (Carica papaya L.) PADA TIKUS JANTAN GALUR WISTAR

Winata, Daniel Chriesdyan (2022) UJI AKTIVITAS DIURETIK TABLET EFFERVESCENT EKSTRAK BIJI PEPAYA (Carica papaya L.) PADA TIKUS JANTAN GALUR WISTAR. Skripsi thesis, Universitas Setia Budi.

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Abstract

Effervescent are uncoated tablets containing acid, base, active and other substances. Papaya seeds contains alkaloids that has diuretic activity. This research is aim to gain formulation of effervescent tablets with a papaya seeds extract (Carica papaya L.) that fulfill quality requirements and determine the effect of it in increasing urine voume of white rats (Rattus norvegicus) for six hours. This research experimentally using two formulations with each of them have 61 and 122 milligrams active substances. Effervescent tablets are made by wet granulation method and molded it with average tablets weights were 1500 milligrams. Also, these tablets were tested for physical qualities. In amount of twenty male rats were classified into 4 gorups. The first group was negative control of solution effervescent tablets with no extract. The second group was positive control of furosemide suspension with range of doses in rats were 0,72mg/200gBB. The third group was effervescent tablets solution with a papaya seeds extract range of doses in rats were1,54mg/200gBB. The fourth group was effervescent tablets with a papaya seeds extract with range of doses in rats were 1,54mg/200gBB. All of the groups orally given loading doses of 4 milliliters warm water and respective test preparations in thirty minutes later. Measurement of urine volume tested in each hour during six hours. The result of this research shows that papaya seeds extract (Carica papaya L.) can be formulated to be effervescent tablets that fulfilled quality requirements. Both AUC values and percentage of DD were parameters that describe how the diuretic activities in the treatmens groups. The result of ANOVA test of the third group shows the diuretic effect is same as the postive control group and the fourth group shows that the effect of the diuretic is better than the first and third groups. Key words: Formulation; effervescent tablets; papaya seeds extract; diuretic

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Formulation; effervescent tablets; papaya seeds extract; diuretic
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	29 Sep 2022 04:38
Last Modified:	29 Sep 2022 04:38
URI:	http://repo.setiabudi.ac.id/id/eprint/5270

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