PENGARUH VARIASI KONSENTRASI CARBOPOL 940 TERHADAP MUTU FISIK GEL HAND WASH EKSTRAK DAUN KERSEN (Muntingia calabura L.) TERHADAP BAKTERI Staphylococcus aureus ATCC 25923

Pratiwi, Dhea Ayu (2022) PENGARUH VARIASI KONSENTRASI CARBOPOL 940 TERHADAP MUTU FISIK GEL HAND WASH EKSTRAK DAUN KERSEN (Muntingia calabura L.) TERHADAP BAKTERI Staphylococcus aureus ATCC 25923. Skripsi thesis, Universitas Setia Budi.

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Abstract

Kersen leaves have antibacterial activity against Staphylococcus aureus. Kersen leaves are shunned to contain active compounds which act as antibacterial is flavonoids, saponins and tannins. The development of the preparation in the form of a hand wash gel because it has a hydrogel formulation that can increase comfort in use. The purpose of this study is to determine the effect of variations in carbopol concentration 940 on physical quality and stability and good activity on S. aureus bacteria. Kersen leaf extract was obtained using the maceration method with 96% ethanol solvent. Hand wash gel formulations are made with variations in carbopol concentrations of 940 1.0; 1.5; and 2.0%. Physical quality hand wash gel was tested organoleptics, homogeneity, viscosity, spread power, stickiness, and pH. Antibacterial activity was tested using the disc diffusion method. Data on physical quality test results and inhibitory zone diameters are analyzed statistically with the Shapiro-wilk test and continued with the One Way Anova test. The results of this study were found that based on physical quality testing and stability and antibacterial activity of the preparation showed variations in carbopol concentrations of 940 1.0; 1.5; and 2.0% have an influence on increasing viscosity, sticky power, and decreased spread of hand wash gel preparations and has good antibacterial activity against Staphylococcus aureus. Formula II is the best formula with a carbopol concentration of 1.5% and the average resistance is 15,69 mm. Keywords : Carbopol 940, Muntingia calabura L, hand wash gel, Staphylococcus aureus.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Carbopol 940, Muntingia calabura L, hand wash gel, Staphylococcus aureus.
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	29 Sep 2022 04:38
Last Modified:	29 Sep 2022 04:38
URI:	http://repo.setiabudi.ac.id/id/eprint/5276

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