Seputri, Iga (2022) LITERATUR REVIEW TANAMAN OBAT DENGAN EFEK HEPATOPROTEKTOR PADA HEWAN UJI YANG DIINDUKSI DIABETES. Skripsi thesis, Universitas Setia Budi.
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Abstract
Diabetes mellitus is a chronic disease that generally occurs due to an increase in blood glucose levels and describes a metabolic disease, known as hyperglycemia. Under conditions of hyperglycemia, it is considered that it has the potential to increase ROS levels and reduce the antioxidant defenses of enzymatic and non-enzymatic cells. Increased ROS causes oxidative stress which results in beta cell dysfunction, liver damage, and insulin resistance. The purpose of this study was to determine the potential and outcome of the hepatoprotective effect of medicinal plants in test animals induced by diabetes. This research uses literature study. The data obtained comes from national and international journals and is searched through databases such as Google Scholar, Science Direct and PubMed. The literature obtained was then screened and reduced according to the inclusion criteria of 16 articles and 100 articles were excluded. The most potential plant to be developed was Stereospermum suaveolens with an extract dose of 400 mg/kgBW, it was found a decrease in lipid peroxidation (p<0.001), an increase in antioxidant enzymes (p<0.001), a decrease in ALT, AST and ALP levels, as well as improvements in lobular structure, mild degeneration. and slight neutrophil infiltration is almost normal. Keywords: Hepatoprotectors, Diabetes, Oxidative Stress, In Vivo
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Hepatoprotectors, Diabetes, Oxidative Stress, In Vivo |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 10 Oct 2022 07:29 |
| Last Modified: | 10 Oct 2022 07:29 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/5319 |
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