UJI AKTIVITAS ANALGETIK EKSTRAK ETANOL RIMPANG BANGLE (Zingiber purpureum Roxb.) PADA TIKUS PUTIH JANTAN DENGAN METODE WRITHING TEST DAN METODE TAIL FLICK

Shahira, Iyem (2018) UJI AKTIVITAS ANALGETIK EKSTRAK ETANOL RIMPANG BANGLE (Zingiber purpureum Roxb.) PADA TIKUS PUTIH JANTAN DENGAN METODE WRITHING TEST DAN METODE TAIL FLICK. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Pain was the most commonly symptom to alert the body that something unusual happens, such as inflammation. One of many kinds of plant that can be used to treat pain was Zingiber purpureum Roxb rhizome. The objectives of this study is to determine analgesic activy of ethanol extract rhizome bangle and effective dose of ethanol extract rhizome bangle (Zingiber purpureum Roxb) which can lead to the highest analgesic effect. Bangle rhizome was extracted by maceration method using 96% ethanol solvent. This study used Tail flick and Writhing test method at 25 male divided into five groupes. Group I as negative control was administered 0,1% CMC, group II as positive control was administered tramadol and acid mefenamic, group III, IV, and V was administered extract of bangle rhizome. The data obtained were analyzed by ANOVA test. The result of the research showed that extract doses 30,843 mg/200 g BB, 61,686 mg/ 200 g BB, and 123,372 mg/ 200 g BB compare with positive control was are significantly differ to group that was given negative control. Extract dose 123,372 mg/ 200 gB compare with positive control was indicated that extract doses 123,372mg/ 200 g BB showed the highest analgesic activity. Alkaloid and flavonoid compounds contained in zingiber purpureum rhizome are thought to have an analgesic effect. Keywords : analgesic, tail flick, writhing test, rhizome bangle

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	analgesic, tail flick, writhing test, rhizome bangle
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	23 Feb 2019 02:48
Last Modified:	23 Feb 2019 02:48
URI:	http://repo.setiabudi.ac.id/id/eprint/536

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