ANALISIS PENAMBATAN MOLEKULER TERHADAP PROTEIN TARGET COVID-19 DAN PREDIKSI PROFIL FARMAKOKINETIKA KANDUNGAN KIMIA TANAMAN TIN (Ficus carica L.)

ROZZAAQ, MUHAMMAD ABDUL (2021) ANALISIS PENAMBATAN MOLEKULER TERHADAP PROTEIN TARGET COVID-19 DAN PREDIKSI PROFIL FARMAKOKINETIKA KANDUNGAN KIMIA TANAMAN TIN (Ficus carica L.). Skripsi thesis, Universitas Setia Budi.

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Abstract

COVID-19 or known as coronavirus is one of the pathogenic viruses that attack the human respiratory system. COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Fig plants (Ficus carica L.) have antiviral activity by preventing virus absorbtion and penetration and inhibiting viral replication. This study aims to find out the prediction of affinity and interaction patterns as well as the ADMET profile of compounds contained in fig plants. The study used the plant tin molecular propagation method (Ficus carica L.) as a test compound and PLpro, 3CLpro, and RdRp as the target protein COVID-19. Docking molecular uses PLANTS, YASARA, Vega ZZ, MarvinSketch, and Biovia DS software. The results showed several plant tin compounds that had good affinity values, amino acid interactions at play, and binding pockets similar to native ligands. Quercetin, luteolin, kaempferol, lupeol, kafeic acid, and ferulic acid compounds have good interaction patterns, affinities, and binding pockets to the target protein COVID-19. The ADMET profile prediction in this study obtained by kafeic acid and ferulatic acid compounds had good ADMET results so that both compounds are predicted to have the best pharmacokinetic profile and have good interaction with the target protein COVID-19. Keywords : COVID-19, figs, Ficus carica L., docking molecular, PLANTS, ADMETLab 2.0

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	COVID-19, figs, Ficus carica L., docking molecular, PLANTS, ADMETLab 2.0
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	10 Oct 2022 07:31
Last Modified:	10 Oct 2022 07:31
URI:	http://repo.setiabudi.ac.id/id/eprint/5372

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