FORMULASI DAN UJI AKTIVITAS SEDIAAN SERUM EKSTRAK ETANOL DAUN TEH HIJAU (Camelia sinensis L.) TERHADAP BAKTERI Staphylococcus epidermidis PENYEBAB JERAWAT

Cahyaningtiyas, Munika (2022) FORMULASI DAN UJI AKTIVITAS SEDIAAN SERUM EKSTRAK ETANOL DAUN TEH HIJAU (Camelia sinensis L.) TERHADAP BAKTERI Staphylococcus epidermidis PENYEBAB JERAWAT. Skripsi thesis, Universitas Setia Budi.

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Abstract

Acne is an abnormal condition of the skin due to overproduction of oil glands. One of the triggers of inflammation in acne is the bacterium Staphylococcus epidermidis. Green tea leaves (Camellia sinensis L.) contain catechins and flavonoids that can inhibit bacterial growth. The purpose of this study was to formulate a serum preparation of green tea leaf extract with good physical quality and to test its activity against Staphylococcus epidermidis bacteria. Extraction of green tea leaves using maceration method with 70% ethanol as solvent. Green tea leaf extract with a concentration of 8% was formulated in the form of serum with various gelling agent carbopol 0.25%, 0.5%, 0.75%, and 1%, as well as other constituents such as glycerin, methyl paraben, triethanolamine and aquadest. The serum preparations were tested for physical quality (organoleptic, homogenity, pH, viscosity, and dispersibility) and tested for stability using the cycling test method. Antibacterial activity testing was carried out using the disc diffusion method. The results of the physical quality test and the antibacterial activity test of the preparation were analyzed using the SPSS Statistic 21 program with one way Anova and Post Hoc. The results of research showed that the variation of carbopol concentration affected the physical quality and antibacterial activity of serum preparations. The formula for serum preparation of green tea leaf ethanol extract with carbopol 0.75% meet the best physical quality and had antibacterial activity against the bacteria Stapylococcus epidermidis that causes acne. Keywords : acne, green tea leaves, carbopol, serum, antibacterial

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	acne, green tea leaves, carbopol, serum, antibacterial
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	10 Oct 2022 07:31
Last Modified:	10 Oct 2022 07:31
URI:	http://repo.setiabudi.ac.id/id/eprint/5376

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