PENGARUH PENAMBAHAN PEMANIS PADA SIRUP EKSTRAK DAUN KEMANGI (Ocimum sanctum) TERHADAP MUTU FISIK DAN EFEK HEPATOPROTEKTOR PADA TIKUS JANTAN (Rattus norvegicus) GALUR WISTAR YANG DIINDUKSI CCL4

NURSAFITRI, DESI (2022) PENGARUH PENAMBAHAN PEMANIS PADA SIRUP EKSTRAK DAUN KEMANGI (Ocimum sanctum) TERHADAP MUTU FISIK DAN EFEK HEPATOPROTEKTOR PADA TIKUS JANTAN (Rattus norvegicus) GALUR WISTAR YANG DIINDUKSI CCL4. Skripsi thesis, Universitas Setia Budi.

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Abstract

Kemangi leaves are medicinal plants that contain flavonoids which medium antioxidant activity and have the potential as hepatoprotectors. The effectiveness of natural antioxidants from the kemangi leaf plant can be improved by formulating the kemangi leaf extract into a syrup preparations. The purpose of this study was to determine the effect of administration of kemangi leaf extract syrup on the levels of SGPT and SGOT in CCl4 induced rats. Simplicia of basil leaves was extracted with 96% ethanol. Basil leaf extract is formulated into syrup preparations with sweetener ratios, namely sucralose, socrose, and unsweetened. The syrup preparations were tested for physical quality for 4 weeks. Orally to the rats for 11 consecutive days each group, on the 12th day the rats were give CCl4, and the SGPT and SGOT levels were tesed on the 13th day. The data were processed using Shapiro-wilk statistics, ANOVA and continued with the Post Hoc Test, namely Tukey. The result showed that the preparation of basil leaf syrup could significanly reduce the activity of SGPT and SGOT in male rats of the wistar strain induced by CCl4. The physical quality of basil leaf syrup preparations with different use of sweeteners did not affect the hepatoprotector effect and viscosity, and pH, but did affect the organoleptic of the basil leaf ectract syrup preparations. Keywords : CCl4; hepatoprotector; Ocimum sanctum; sweetener;

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	CCl4; hepatoprotector; Ocimum sanctum; sweetener;
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	30 Nov 2022 04:14
Last Modified:	30 Nov 2022 04:14
URI:	http://repo.setiabudi.ac.id/id/eprint/5476

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