Hamid, Ezzy Al Bazzy Abdul Hasan (2022) UJI AKTIVITAS ANTIOKSIDAN SEDIAAN LOTION FRAKSI NHEKSAN, ETIL ASETAT DAN AIR DARI EKSTRAK DAUN SIRSAK (Annona Muricata L.) DENGAN METODE DPPH. Skripsi thesis, Universitas Setia Budi.
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Abstract
The lotion preparation serves to protect the skin of the human body from the environment such as weather and climate. Soursop leaf (Annona muricata L.) is a plant that contains antioxidant compounds that can be used to protect the skin from damage caused by free radicals. This research was conducted to determine the antioxidant activity content of the soursop leaf fraction after being made into lotion preparations. The research was conducted by maceration extraction method using 70% ethanol solvent, then fractionation using n-hexane, ethyl acetate and water as solvent with liquid-liquid extraction method was carried out. The obtained fraction was then formulated into a lotion preparation which was divided into F1 as a base without containing the active substance, F2 containing the nhexane fraction, F3 containing the ethyl acetate fraction and F4 containing the water fraction. The concentration of the active substance in the lotion preparation was 2.8% each. The lotion preparations were tested for physical quality including organoleptic, homogeneity, pH, viscosity, dispersibility and stability tests. The fraction and lotion preparation were then tested for antioxidant activity using the DPPH method. The results showed that the fraction of n-hexane, ethyl acetate and soursop leaf water had an effect on the physical quality and antioxidant activity of lotion preparations. F1 and F3 are preparations that are stable to the physical quality of lotion preparations. F3 is the best preparation to produce semi-solid preparations, brown in color, citrus aroma, pH value 5.12; viscosity 176.67 dPas, spreading power 6.67-6.87 cm. F2 and F4 are not stable to the physical quality of homogeneity because there is a phase separation caused by the nature of the active substance, namely non-polar and polar. Antioxidant activity was carried out on positive controls of quercetin, n-hexane fraction, ethyl acetate fraction, water fraction and lotion preparations. The results of the antioxidant activity test showed that the IC50 value of quercetin was 31.586 ppm, the nhexane fraction was 118.112 ppm, the ethyl acetate fraction was 57.428 ppm, the water fraction was 66.123 ppm, F1 336.512 ppm, F2 182.323 ppm, F3 129, 232 ppm, and F4 144.377 ppm. Research on the antioxidant activity test of the fractions of n-hexane, ethyl acetate and soursop leaf water after being made in the form of a lotion, the antioxidant activity decreased. Keywords: Lotion, antioxidant, soursop leaf fraction
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Lotion, antioxidant, soursop leaf fraction |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 30 Nov 2022 04:18 |
| Last Modified: | 30 Nov 2022 04:18 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/5497 |
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