UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL FRAKSI n-HEKSAN, ETIL ASETAT DAN AIR DARI DAUN DADAP SEREP (Erythrina lithosperma Miq.) TERHADAP BAKTERI Streptococcus mutans

Widiardana, I Putu Ananta Krisna (2022) UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL FRAKSI n-HEKSAN, ETIL ASETAT DAN AIR DARI DAUN DADAP SEREP (Erythrina lithosperma Miq.) TERHADAP BAKTERI Streptococcus mutans. Skripsi thesis, Universitas Setia Budi.

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Abstract

Dental caries is a progressive destruction of enamel, dentin and cementum, initiated by microbial activity on the surface of the tooth that is prone to damage. One of the bacteria that causes dental caries is Streptococcus mutans. serep leaves (Erythrina lithosperma Miq.) contain many antibacterial compounds such as alkaloids, flavonoids, saponins and tannins which are effective in suppressing the emergence of bacteria. This study was aimed to determine the antibacterial activity of ethanol extract, n-hexane, ethyl acetate and dadap serep leaf water on Streptococcus mutans bacteria. Dadap serep leaf powder was extracted by maceration method using 96% ethanol as solvent. Dadap serep leaf extract obtained was then fractionated using n-hexane, ethyl acetate and water as solvents. The ethanol extract and fraction were tested for their antibacterial activity by diffusion method with concentrations of 20, 40 and 60% to determine the most active fraction. The most active fraction was then continued with the dilution test with variations in concentration, namely, 60; 30; 15; 7.5; 3.75; 1.875% to determine the Minimum Kill Concentration. The results showed that the extract and fraction of dadap serep leaves had antibacterial activity against Streptococcus mutans. The ethyl acetate fraction with a concentration of 60% had the most active antibacterial activity with an average inhibition zone diameter of 15.5 mm. Minimum killing concentration of ethyl acetate fraction against Streptococcus mutans was 7.5%. Keywords: dental caries, dadap serep, Streptococcus mutans, fraction, antibacterial

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	dental caries, dadap serep, Streptococcus mutans, fraction, antibacterial
Subjects:	R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	30 Nov 2022 04:17
Last Modified:	30 Nov 2022 04:17
URI:	http://repo.setiabudi.ac.id/id/eprint/5516

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