UJI AKTIVITAS ANTIPIRETIK EKSTRAK ETANOL DAN FRAKSI AIR DAUN SIRSAK (Annona muricata L.) PADA TIKUS PUTIH (Rattus norvegicus) JANTAN YANG DIINDUKSI PEPTON

Melaningsih, Melaningsih (2022) UJI AKTIVITAS ANTIPIRETIK EKSTRAK ETANOL DAN FRAKSI AIR DAUN SIRSAK (Annona muricata L.) PADA TIKUS PUTIH (Rattus norvegicus) JANTAN YANG DIINDUKSI PEPTON. Skripsi thesis, Universitas Setia Budi.

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Abstract

Soursop (Annona muricata L.) has flavonoid chemical compounds that have traditionally been used in the treatment of fever. This study aimed to determine the antipyretic activity of ethanol extract and water fraction of soursop leaves in male white rats (Rattus norvegicus) as an antipyretic equivalent to paracetamol. Soursop leaf extract was prepared using the maceration method followed by liquid-liquid fractionation and then antipyretics testing was carried out using 20 male white rats, which were divided into 4 groups, namely negative control (CMC Na), positive control (paracetamol), soursop leaf extract group with a dose of 400 mg/kg BW rats and water fraction of soursop leaves with a dose of 240 mg/kg BW rats. Mice were induced by fever using 5 % peptone subcutaneously. Rectal temperature measurement were taken every 30 minutes to 120 minutes after oral administration using a digital thermometer. The data obtained were T0, T1 fever, and rectal temperature measurement at each time interval. These data were used to calculate AUC and the average AUC calculation data were analyzed using the Shapiro wilk test and the one way ANOVA test. The results showed that the ethanol extract at a dose of 400 mg/kg BW and the water fraction of soursop leaves at a dose 240 mg/kg BW could provide an antipyretic effect in tests animals, which was equivalent to paracetamol as a positive control. Keywords: antipyretic, Annona muricata L, Pepton

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	antipyretic, Annona muricata L, Pepton
Subjects:	R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	30 Nov 2022 04:18
Last Modified:	30 Nov 2022 04:18
URI:	http://repo.setiabudi.ac.id/id/eprint/5547

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