PENGARUH HPMC TERHADAP MUTU FISIK DAN STABILITAS EMULGEL MINYAK ATSIRI BIJI JINTEN HITAM (Nigellae sativae semen) TERHADAP BAKTERI Staphylococcus epidermidis

Octaviani, Milla (2022) PENGARUH HPMC TERHADAP MUTU FISIK DAN STABILITAS EMULGEL MINYAK ATSIRI BIJI JINTEN HITAM (Nigellae sativae semen) TERHADAP BAKTERI Staphylococcus epidermidis. Skripsi thesis, Universitas Setia Budi.

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Abstract

Staphylococcus epidermidis plays a role in the pathogenesis of acne by producing metabolites that can react with sebum, thereby increasing the inflammatory process. The purpose of this study was to determine the effect of hpmc concentration on the physical properties, stability, and antibacterial activity of Staphylococcus epidermidis bacteria. Black cumin seed essential oil was obtained from Darjeeling to be identified specific gravity, refractive index, solubility and GC-MS. After that it was formulated into an emulgel with variations in the concentration of hpmc gel base 3%, 3.5% and 4%. Emulgel was tested for physical quality and stability test. Antibacterial activity test was carried out by well diffusion method. Data analysis using One Way Anova. The results showed that the black cumin seed essential oil emulgel had good physical quality and was good for organoleptic, homogeneity, pH, viscosity, spreadability, adhesion and emulsion type and had antibacterial activity against Staphylococcus epidermidis with inhibition zones at concentrations of 3%, 3.5%, and 4%, namely 19.25 mm, 17.43 mm and 15.8 mm. The results showed that the emulgel concentration of 3% was the most active. Keyword : Emulgel, Black cumin, hpmc, Staphylococcus epidermidis

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Emulgel, Black cumin, hpmc, Staphylococcus epidermidis
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	30 Nov 2022 03:19
Last Modified:	30 Nov 2022 03:19
URI:	http://repo.setiabudi.ac.id/id/eprint/5551

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