UJI AKTIVITAS GEL SUNSCREEN EKSTRAK KULIT BUAH MANGGIS (Garcinia mangostana L.) SECARA IN VITRO MENGGUNAKAN SPEKTROFOTOMETER UV VIS

Shofa, Mukammilatush (2022) UJI AKTIVITAS GEL SUNSCREEN EKSTRAK KULIT BUAH MANGGIS (Garcinia mangostana L.) SECARA IN VITRO MENGGUNAKAN SPEKTROFOTOMETER UV VIS. Skripsi thesis, Universitas Setia Budi.

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Abstract

Excessive ultraviolet light radiation gives several disorders and degenerative conditions. Prevention is done by avoiding excessive sun exposure, consuming antioxidants, and using sunscreen. Mangosteen peel contains xanton compounds, flavonoids and tannins which have activity as a sunscreen. The purpose of this study was to formulate a gel preparation of mangosteen peel extract with good physical quality and stability, and to determine its activity as a sunscreen. Extraction of mangosteen peel using maceration method with 70% ethanol solvent. Mangosteen peel extract with 0.2% concentration was formulated in the form of a gel with a variation of gelling agent viscolam MAC 10 with a concentration of 5%; 8%; 10% and negative control (8%). The gel preparations were tested for physical quality (organoleptic, homogeneity, pH, viscosity, spreadability, adhesion) and stability of the cycling test method. The sunscreen activity test was analyzed in vitro using a UV Visible spectrophotometer at a wavelength of 290nm-320nm at 5nm intervals. The results were analyzed using IBM SPSS statistics 26 One Way ANOVA and post Hoc. The results showed that gel preparations with variations in viscolam concentrations affected activity as a sunscreen, and physical quality which included pH, viscosity, spreadability, and adhesion, but had no effect on organoleptic and homogeneity. Formula III preparation of mangosteen peel extract gel with 8% viscolam meets the best physical quality and has an SPF value as a sunscreen with a maximum protection of 10,129. Keywords : mangosteen rind; gel; sunscreen; viscolam

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	mangosteen rind; gel; sunscreen; viscolam
Subjects:	R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	30 Nov 2022 04:19
Last Modified:	30 Nov 2022 04:19
URI:	http://repo.setiabudi.ac.id/id/eprint/5556

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