UJI AKTIVITAS TABLET HISAP EKSTRAK DAUN KEPEL (Stelechocarpus burahol Hook F.&Th) DALAM MENURUNKAN KADAR ASAM URAT PADA MENCIT PUTIH JANTAN (Mus musculus)

Pratiwi, Pipit Putri (2022) UJI AKTIVITAS TABLET HISAP EKSTRAK DAUN KEPEL (Stelechocarpus burahol Hook F.&Th) DALAM MENURUNKAN KADAR ASAM URAT PADA MENCIT PUTIH JANTAN (Mus musculus). Skripsi thesis, Universitas Setia Budi.

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Abstract

Lozenges are tablets that contain one or more medicinal ingredients, generally with an aromatic base and are expected to disintegrate slowly in the mouth. Kepel leaf is a medicinal plant that can be used to treat gout. Kepel leaves contain flavonoid chemical compounds that have properties as lowering uric acid levels. The purpose of this study was to determine the physical quality, activity of lowering uric acid levels, and the effective dose of lozenges of Kepel leaf extract as lowering uric acid levels. This research uses maceration extraction method because it is easy, economical, and simple with 70% ethanol as solvent. Lozenges were made by wet granulation and molded using an average weight of 1000 mg and tested for physical quality. The uric acid-lowering activity test used 25 male white mice induced by caffeine and grouped into five groups. Group 1 was a negative control of lozenges without extract, group 2 was a positive control of allopurinol suspension, group 3 was a solution of a lozenge of kepel leaf extract at a dose of 100mg/KgBB, group 4 a solution of a lozenge of a kepel leaf extract at a dose of 150mg/KgBW and a group 5 a solution of a lozenge of a leaf extract. Kepel dose 200mg/KgBB. All groups were induced by caffeine for 6 days and then taken orally with their respective test preparations. Observations of decreasing uric acid levels were carried out on the 9th day, 12th day, and 15th day. The results showed that the ethanol extract of kepel leaves (Stelechocarpus burahol Hook F.&Th.) could be formulated into lozenges that had good physical quality. All formulas can reduce uric acid levels in mice by obtaining a percentage decrease in uric acid levels at a dose of 100mg/kgBW of 81%, a dose of 150mg/kgBW of 83%, and a dose of 200mg/kgBW of 89%. The BNT test using the LSD method showed that the 100mg/KgBW dose test group was significantly different (p≤0.05) with the positive control, while 150mg/KgBW and 200mg/kgBW showed no significant difference (p≥0.05) with the positive control. Keywords : Kepel leaf, lozenges, uric acid, caffeine, formulation

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Kepel leaf, lozenges, uric acid, caffeine, formulation
Subjects:	R Medicine > RS Pharmacy and materia medica R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	30 Nov 2022 02:45
Last Modified:	30 Nov 2022 02:45
URI:	http://repo.setiabudi.ac.id/id/eprint/5589

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