UJI DISOLUSI TERBANDING DAN PENETAPAN KADAR TABLET SALUT ENTERIK ASETOSAL YANG BEREDAR DI MASYARAKAT

ADINENGSIH, RATIH SRI (2022) UJI DISOLUSI TERBANDING DAN PENETAPAN KADAR TABLET SALUT ENTERIK ASETOSAL YANG BEREDAR DI MASYARAKAT. Skripsi thesis, Universitas Setia Budi.

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Abstract

Acetosal is a class II Biopharmaceutical Classification System (BCS) class drug with high permeability but low solubility properties. This research was carried out to determine the quality of acetosal preparations circulating in the community through physical quality tests in the form of tests of uniformity of weight, hardness, fragility and crushing time; dissolution test; and determination of levels using ultraviolet spectrophotometry. The dissolution test method was adopted from the Indonesian Pharmacopoeia Edition VI and the sample filtrate was tested using ultraviolet spectrophotometry. The test was carried out on five samples, namely one sample of innovator acetosal tablets and four samples of acetosal copy products (acetosal products abroad, two samples of acetosal tablets of PMDN products and one sample of acetosal tablets from private companies of Indonesia). The results showed that samples of innovator tablets and several enteric acetosal-coated tablet products circulating in the community met all the criteria of physical quality, and tablet levels. Sample B shows a dissolution profile similar to the innovator while the product ( C, D and E) shows a dissolution profile not similar to the innovator product, although samples C, D and E do not have a similar dissolution profile but still meet the requirements of the dissolution test. Keywords : Acetosal, dissolution, grade determination, physical quality, uv spectrophotometry

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Acetosal, dissolution, grade determination, physical quality, uv spectrophotometry
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	30 Nov 2022 04:19
Last Modified:	30 Nov 2022 04:19
URI:	http://repo.setiabudi.ac.id/id/eprint/5594

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