FORMULASI TABLET HISAP EKSTRAK DAUN SIRIH (Piper betle L.) DENGAN METODE GRANULASI BASAH MENGGUNAKAN VARIASI KONSENTRASI GELATIN SEBAGAI BAHAN PENGIKAT

Ramadanti, Resy Budi (2022) FORMULASI TABLET HISAP EKSTRAK DAUN SIRIH (Piper betle L.) DENGAN METODE GRANULASI BASAH MENGGUNAKAN VARIASI KONSENTRASI GELATIN SEBAGAI BAHAN PENGIKAT. Skripsi thesis, Universitas Setia Budi.

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Abstract

Lozenges are tablets that are sucked in the mouth, not crushed directly but crushed slowly for about 30 minutes with a flavor enhancer. Betel leaf extract contains essential oils, tannins, saponins, and flavonoids that are useful as astringent, antibacterial and antifungal agents. This study aims to formulate lozenges of betel leaf extract with varying concentrations of gelatin as a binder that meets the requirements of the physical quality of the tablet. The thick extract of betel leaf was obtained by maceration using 70% ethanol as solvent. Betel leaf extract lozenges were made with three formulas and varying the concentration of the gelatin binder by 5%, 7.5%, and 10%. Lozenges are made by wet granulation method. The granules were tested for physical properties including moisture content, compressibility, flow time and angle of repose. The lozenges were tested for physical properties including weight uniformity, hardness, friability, dissolving time and taste response test (Hedonic test). The data obtained were analyzed statistically using the Shapiro-wilk test and the One Way Anova test with a 95% confidence level. The results showed that the formula of betel leaf extract lozenges with gelatin as a binder at concentrations of 5%, 7.5%, and 10% produced lozenges that met the requirements. The results showed that variations in the concentration of gelatin have an effect on the physical properties of the granules, namely flow time, the higher the concentration of the gelatin binder, the shorter the flow time of the granules. As well as having an effect on the physical properties of lozenges, namely tablet hardness, the higher the concentration of the gelatin binder, the higher the tablet hardness. Keyword : Lozenges, betel leaf extract, gelatin, wet granulation

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Lozenges, betel leaf extract, gelatin, wet granulation
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	30 Nov 2022 02:59
Last Modified:	30 Nov 2022 02:59
URI:	http://repo.setiabudi.ac.id/id/eprint/5602

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