FORMULASI DAN UJI ANTIBAKTERI SEDIAAN EMULGEL EKSTRAK DAUN SIRIH HIJAU (Piper Betle L.) TERHADAP Propionibacterium acne DENGAN VARIASI KONSENTRASI KARBOPOL 940

Arianto, Ifan (2023) FORMULASI DAN UJI ANTIBAKTERI SEDIAAN EMULGEL EKSTRAK DAUN SIRIH HIJAU (Piper Betle L.) TERHADAP Propionibacterium acne DENGAN VARIASI KONSENTRASI KARBOPOL 940. Skripsi thesis, Universitas Setia Budi.

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Abstract

Compounds in green betel leaf extract that are thought to have antibacterial activity are polar compounds such as flavonoids, tannins, saponins and polyphenols. One of the important components in emulgel preparations is the gelling agent, carbopol 940 is used because it can form emulgels well and increase the viscosity. This study was conducted to determine variations in the concentration of carbopol 940 on the physical quality and stability of emulgel preparations of green betel leaf extract and to determine the activity of chemical compounds contained in green betel leaf extract of emulgel preparations which have antibacterial activity. Green betel leaf extract was obtained by maceration using 70% ethanol. The emulgel formulation uses an extract concentration of 5% and variations of carbopol 940 1%, 1.5%, and 2%, by mixing the gel phase and the emulsion phase. Green betel leaf emulgel preparations were tested for physical quality including organoleptic tests, homogeneity, spreadability, adhesion, pH, viscosity, and emulsion type as well as stability tests using freeze thaw. Antibacterial testing used the disc diffusion method and one-way ANOVA for statistical analysis. Variations in the concentration of carbopol 940 affect the physical quality and stability of emulgel preparations, especially in the pH, viscosity, spreadability, and adhesion tests. The best formula is formula I with variations in the concentration of carbopol 940 1% which produces the best physical quality and stability. The diameter of the inhibition zone for Emulgel Formula 1 preparation was 14.93 mm and it has strong antibacterial activity in inhibiting the growth of Propionibacterium acne. Keywords: green betel leaf, emulgel, gelling agent, carbopol 940, Propionibacterium acne

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	green betel leaf, emulgel, gelling agent, carbopol 940, Propionibacterium acne
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	05 Apr 2023 03:01
Last Modified:	05 Apr 2023 03:01
URI:	http://repo.setiabudi.ac.id/id/eprint/5786

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