PENGARUH KOMBINASI PROPILEN GLIKOL DAN LAKTOSA DALAM PEMBUATAN TABLET LIQUISOLID NIFEDIPIN DENGAN METODE KEMPA LANGSUNG

Lindawati, Lindawati (2022) PENGARUH KOMBINASI PROPILEN GLIKOL DAN LAKTOSA DALAM PEMBUATAN TABLET LIQUISOLID NIFEDIPIN DENGAN METODE KEMPA LANGSUNG. Skripsi thesis, Universitas Setia Budi.

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Abstract

Nifedipine is a water-insoluble drug, its water dissolution rate is quite low, so it requires efforts to increase its dissolution and improve its bioavailability. The purpose of this study was to determine the impact and comparison of Propylene Glycol as a non-volatile solvent and lactose as an absorbent (carrier material) on the physical properties of the Nifedipine liquisolid tablets and to determine the dissolution profile of the Nifedipine liquisolid tablets. This study used samples of Nifedipine which were formulated using propylene glycol and lactose excipients using the direct compression method with a ratio of formula 1 (5% propylene glycol : 95% lactose), formula 2 (10% propylene glycol : 95% lactose), formula 3 (15 % propylene glycol : 85% lactose). Tests performed on the manufacture of Nifedipine liquisolid tablets included physical tests of tablets and dissolution rate. Research data were analyzed using One way ANOVA. The results showed that propylene glycol had a significant effect on increasing friability, dissolution, content uniformity, and tablet disintegration time, while lactose had a significant effect on increasing tablet hardness. The interaction of the two has a significant effect on increasing the uniformity of tablet content. A good formula from all physical quality tests and dissolution tests is contained in formula 3 with a ratio of propylene glycol: lactose (15%: 85%). Keywords: Nifedipine liquisolid, propylene glycol, lactose, dissolution, tablet physical quality test

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Nifedipine liquisolid, propylene glycol, lactose, dissolution, tablet physical quality test
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	05 Apr 2023 03:00
Last Modified:	05 Apr 2023 03:00
URI:	http://repo.setiabudi.ac.id/id/eprint/5798

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