PENGARUH VARIASI KONSENTRASI ASAM STEARAT TERHADAP MUTU FISIK SEDIAAN KRIM EKSTRAK PEGAGAN (Centella asiatica Urb.) SEBAGAI ANTIOKSIDAN

Agustina, Maudy (2023) PENGARUH VARIASI KONSENTRASI ASAM STEARAT TERHADAP MUTU FISIK SEDIAAN KRIM EKSTRAK PEGAGAN (Centella asiatica Urb.) SEBAGAI ANTIOKSIDAN. Skripsi thesis, Universitas Setia Budi.

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Abstract

(Centella asiatica Urb.) is a plant that functions as a strong antioxidant because it contains alkaloids, saponins, tannins, flavonoids, steroids and triterpenoids which can be formulated into cream preparations. Cream is a cosmetic preparation that can give a soft feeling and does not feel greasy when applied topically. The purpose of this study was to determine the effect of varying concentrations of stearic acid on the physical quality of the ethanol extract cream of Centella asiatica Urb. on antioxidant activity. The extract used in this study was obtained by maceration using 70% ethanol. The extract obtained was made into a cream formulation with various concentrations of stearic acid 10,8%; 12,8%; and 14,8%. Examination of the physical quality of the cream preparations includes organoleptic tests, homogeneity, pH, viscosity, spreadability, adhesion, and Cycling test.The method of determining antioxidant activity was carried out by the DPPH method through the percentage of IC50 inhibition.Data processing for each formulation was carried out by statistical analysis of the results using the SPSS (Statistical Package for the Social Sciences) application. Antioxidant activity test resultsgotu kolahas an extract IC50 value of 68,34 ppm. The cream formulation obtained the best formula by fulfilling the physical quality and stability test requirements including pH and viscosity. Variations in stearic acid concentrations affected the physical quality and stability of the ethanol extract antioxidant cream preparationsgotu kola (Centella asiatica Urb.). The best formula is an antioxidant cream with ethanol extract of gotu kola with a concentration of 10.8% stearic acid which has an IC50 value of 112,69 ppm. Keywords: Antioxidant; cream; Centella asiatica Urb; Stearic Acid; DPPH

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Antioxidant; cream; Centella asiatica Urb; Stearic Acid; DPPH
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	05 Apr 2023 02:59
Last Modified:	05 Apr 2023 02:59
URI:	http://repo.setiabudi.ac.id/id/eprint/5801

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