FORMULASI, UJI MUTU FISIK DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN SERUM GEL EKSTRAK ETANOL DAUN KELOR (Moringa oleifera L.) TERHADAP BAKTERI Staphylococcus aureus ATCC 25923

Mahfudh, Muhammad (2022) FORMULASI, UJI MUTU FISIK DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN SERUM GEL EKSTRAK ETANOL DAUN KELOR (Moringa oleifera L.) TERHADAP BAKTERI Staphylococcus aureus ATCC 25923. Skripsi thesis, Universitas Setia Budi.

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Abstract

Staphylococcus aureus is the bacteria that causes acne. Moringa leaf extract has strong antibacterial activity against Staphylococcus aureus bacteria in the presence of active compounds. This study aims to determine the best results from the effect of HEC variations on the physical quality of Moringa oleifera L. serum gel preparations and antibacterial activity against Staphylococcus aureus ATCC 25923. The ethanol extract of Moringa leaves was prepared using the maceration method with 70% ethanol solvent. Moringa leaf 5% ethanol extract was made into 3 serum gel formulas with varying concentrations of hydroxyethylcelluloce (HEC) for F1, F2, and F3 respectively 0.25%, 0.5%, and 1%. All formulas were tested for physical quality including organoleptic test parameters, homogeneity, pH, viscosity, and freeze thaw ftability, as well as antibacterial activity using the disc diffusion method. The results of this study were analyzed using the SPSS 25 statistical method with the one way ANOVA test. The results showed that 5% Moringa leaf extract had an inhibition zone area of 19.40 mm. Variation of HEC concentration of each formula has an influence on the physical quality and antibacterial activity. Formulas that have good physical quality values are found in F2 with 0.5% HEC and antibacterial activity against Staphylococcus aureus ATCC 25923 in F1, F2, and F3 respectively 12.68 mm, 11.43 mm, and 9.89 mm . It can be concluded that the formula that has good antibacterial activity of Staphylococcus aureus ATCC 25923 is found in F1 with HEC 0.25% having an inhibition zone diameter of 12.68 mm which is classified as strong. Keywords: Moringa leaves, gel serum, Staphylococcus aureus ATCC 25923

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Moringa leaves, gel serum, Staphylococcus aureus ATCC 25923
Subjects:	R Medicine > RS Pharmacy and materia medica R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	05 Apr 2023 03:01
Last Modified:	05 Apr 2023 03:01
URI:	http://repo.setiabudi.ac.id/id/eprint/5804

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