Afgarini, Triviana (2023) UJI EFEKTIVITAS EKSTRAK KULIT KENTANG (Solanum tuberosum L.) TERHADAP PENURUNAN KOLESTEROL TOTAL SERTA ANALISIS HISTOPATOLOGI PERLEMAKAN HATI PADA MENCIT (Mus musculus L.) YANG DIINDUKSI HATI AYAM DAN KUNING TELUR PUYUH. Skripsi thesis, Universitas Setia Budi.
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Abstract
Hyperlipidemia is characterized by increased levels of total cholesterol, triglycerides, LDL, VLDL, and HDL. Potato skins contain chlorogenic acid, a class of flavonoids that can lower blood cholesterol levels and prevent oxidation reactions in the body. This study aims to determine the effect of ethanol extract from potato peel in reducing total cholesterol levels in hyperlipidemic male white mice (Mus musculus L.) and determine the effective dose and histopathological analysis of fatty liver. This study used a 70% ethanol solvent maceration method. The test animals used 25 male white mice divided into five groups: the 0.5% CMC group, the simvastatin group, and the potato skin extract group with three dose variations (dose 140, 280, 560 mg/kg BW). The test animals were made hyperlipidemic by induction of chicken liver and quail egg yolk for 14 days, and then total cholesterol levels were measured on days 0, 14, and 28 using the Point of Care Test (POCT). Entire cholesterol data and histopathological scoring were statistically analyzed using the One Way Anova test. The results of this study indicate that giving potato peel extract can reduce cholesterol levels. 280 mg/kgBB is an effective dose. The histopathological effect of giving potato skin extract can reduce fatty liver of male white mice induced by chicken liver and quail egg yolk. Keywords: cholesterol, potato peel extract, liver histopathology
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | cholesterol, potato peel extract, liver histopathology |
| Subjects: | R Medicine > RS Pharmacy and materia medica R Medicine > RV Botanic, Thomsonian, and eclectic medicine |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 05 Apr 2023 02:54 |
| Last Modified: | 05 Apr 2023 02:54 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/5822 |
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