Ivani, Ferryna Nanda (2022) UJI AKTIVITAS ANTIDEPRESAN EKSTRAK DAUN KANGKUNG (Ipomoea aquatica Fork) PADA MENCIT JANTAN GALUR Swiss Webster DENGAN METODE Forced Swimming Test. Skripsi thesis, Universitas Setia Budi.
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Abstract
Depression is a medical disorder that involves decreased levels of neurotransmitters, namely serotonin, norepinephrine, and dopamine. Kale (Ipoema aquatica fork) leaf extract contains a chemical compound in the form of quercetin which is known to have an antidepressant effect. Quersertin has a mechanism of action that inhibits MAO-A and MAO-B enzymes. This study aims to determine the antidepressant activity of kale leaf extract in male mice using the forced swimming test method and to determine the effective dose. This study used the forced swimming test method by observing the immobility time in mice. The test animals used were male mice with a total of 25 tails and divided into 5 groups, including a negative control group using 0.5% CMC Na, a positive control using amitriptyline, and a kale leaf extract group with a dose variation of 1, namely 24 mg/kg BW. ; dose 2 is 48 mg/kg BW; dose 3 is 96 mg/kg BW. Induction of depression using the forced swimming test method was carried out for 7 days. After the mice were induced, they were given treatment until day 14. Immobility time was recorded on day 1; 7th and 14th. The results of this study showed that kale leaf extract at a dose of 24 mg/kg BW; 48 mg/kg BW; 96 mg/kg BW can reduce depression in swiss webster male mice by looking at the immobility time parameter of the mice. The effective dose in reducing depression in mice is a dose of 96 mg/kg BW. Keywords: antidepressants, forced swimming test, immobility time, Ipoema aquatica Fork
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | antidepressants, forced swimming test, immobility time, Ipoema aquatica Fork |
| Subjects: | R Medicine > RV Botanic, Thomsonian, and eclectic medicine |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 12 Apr 2023 01:54 |
| Last Modified: | 12 Apr 2023 01:54 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/5846 |
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