PENGARUH SUHU PENYIMPANAN REFRIGERATOR DAN SUHU RUANG TERHADAP KADAR INJEKSI SEFOTAKSIM SETELAH DIREKONSTITUSI DENGAN NaCl 0,9%

Amalliyah, Dewi Mustika (2023) PENGARUH SUHU PENYIMPANAN REFRIGERATOR DAN SUHU RUANG TERHADAP KADAR INJEKSI SEFOTAKSIM SETELAH DIREKONSTITUSI DENGAN NaCl 0,9%. Skripsi thesis, Universitas Setia Budi.

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Abstract

Cefotaxime sodium is a-lactam antibiotic, which is a 3rd generation cephalosporin that is easily hydrolyzed when reconstituted. Cefotaxime should be diluted with a suitable solvent. Samples after reconstituted should be used immediately. The purpose of this study was to determine the effect of storage temperature on the levels of cefotaxime sodium with 0.9% NaCl solvent. Cefotaxime sodium injection was dissolved in 100 ml of 0.9% NaCl solvent then stored at refrigerator temperature (2 ⸰C-8 ⸰C) and room temperature (25⸰C -30⸰C). Samples were tested for physical quality including organoleptic and pH as well as determination of levels using HPLC with storage times of 0, 1, 3, 5, 7, and 10 days. Levels were analyzed using SPSS with paired-samples t test statistics and independent sample t test. The results showed that the effect of temperature on the storage time of injection of cefotaxime sodium in the organoleptic physical quality test and the pH of the refrigerator temperature was more physically stable than at room temperature. A decrease in the concentration of cefotaxime injection occurs at refrigerator temperature of less than 10% when stored for 10 days and is acceptable according to the provisions of the active substance content in the preparation of 95- 110%, while at room temperature the potency loses less than 10% after 1 day of storage. The effect of storage temperature on the levels of cefotaxime sodium injection preparations shows that at refrigerator temperature it is more stable than at room temperature. Keywords: cefotaxime sodium, temperatur, rate, HPLC

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	cefotaxime sodium, temperatur, rate, HPLC
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	03 Jul 2023 04:30
Last Modified:	03 Jul 2023 04:30
URI:	http://repo.setiabudi.ac.id/id/eprint/5934

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