FORMULASI DAN UJI MUTU FISIK TABLET PITAVASTATIN MENGGUNAKAN VARIASI AVICEL PH 102 DAN LAKTOSA YANG DIBUAT DENGAN METODE KEMPA LANGSUNG

Sandi, Faricha Yunika Yudha (2022) FORMULASI DAN UJI MUTU FISIK TABLET PITAVASTATIN MENGGUNAKAN VARIASI AVICEL PH 102 DAN LAKTOSA YANG DIBUAT DENGAN METODE KEMPA LANGSUNG. Skripsi thesis, Universitas Setia Budi.

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Abstract

Pitavastatin is an anti-cholesterol drug that works by inhibiting the formation of cholesterol by the enzyme 3-hydroxy 3-methylglutaryl coenzyme A (HMG-CoA) reductase. This study aims to determine the effect of varying concentrations of avicel PH 102 as filler-binder and lactose s on the physical quality of tablets made by direct compression and to determine which formula provides the best physical quality and the greatest dissolution. The use of lactose and avicel PH 102 as filler binders can increase the flowability and compactibility of the tablet mass This research was made of three formulas using the composition of lactose and avicel PH 102 as filler-binders with a ratio of formula 1 (44%: 50%), formula 2 (39%: 55%), and formula 3 (34%: 60%). Test characterization included tablet size uniformity test, tablet weight uniformity test, tablet content uniformity test, tablet hardness test, tablet friability test, disintegration time test, and dissolution test. The test results were analyzed using the Way ANOVA analysis method of variance with a 95% confidence level using the SPSS program. The results showed that variations in the concentration of the 3 pitavastatin tablet formulas produced a good physical quality of the tablets. Lactose and avicel PH 102 affect tablet compatibility, tablet fragility, disintegration time, and dissolution. The proportion of lactose was 44% (88 mg) and avicel PH 102 50% (100 mg) resulting in a pitavastatin tablet formula with the best physical tablet quality and the greatest dissolution. Keywords: Pitavastatin tablets, direct compression, avicel PH 102, lactose, tablet physical quality test

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Pitavastatin tablets, direct compression, avicel PH 102, lactose, tablet physical quality test
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	03 Jul 2023 04:29
Last Modified:	03 Jul 2023 04:29
URI:	http://repo.setiabudi.ac.id/id/eprint/5938

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