PERBANDINGAN NILAI AGREGASI TROMBOSIT PADA TIKUS GALUR WISTAR (Rattus norvegicus) DENGAN DIET STANDAR DAN TINGGI LEMAK

Julian, Dhimas Prayoga (2023) PERBANDINGAN NILAI AGREGASI TROMBOSIT PADA TIKUS GALUR WISTAR (Rattus norvegicus) DENGAN DIET STANDAR DAN TINGGI LEMAK. Karya Tulis Ilmiah thesis, Universitas Setia Budi.

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Abstract

Prayoga, Julian Dhimas, 2023. Comparison of Platelet Aggregation Values in Wistar Rats (Rattus norvegicus) with a Standard and High-Fat Diet. D3 Health Analyst Major.Faculty of Health Sciences. Setia Budi University. Hypercholesterolemia is responsible for one third of ischemic stroke cases and is estimated to cause 2.6 million deaths worldwide. Elevated cholesterol levels also accounted for 29.7 million (2%) of the total global cases. Hypercholesterolemia can cause endothelial dysfunction which can trigger an increase in platelet aggregation values which play an important role in the occurrence of cardiovascular disease. This study aims to determine differences in platelet aggregation values between wistar strain rats (Rattus norvegicus) fed a standard diet and a high-fat diet. The research was carried out from February to April 2023 in Setia Budi University Laboratory was using the blood smear method with the calculation of the velaskar formula. The population used was Wistar rats with a mixture of males weighing ≥ 200 grams as many as 10 rats which were divided into 2 groups, namely the group with a standard diet and high fat. The group of rats was given a standard ration with standard feed while the group of rats with a high-fat ration was given a standard diet with the addition of lard and duck egg yolk for 4 weeks. Furthermore, the value of platelet aggregation was examined in both groups and then the data were analyzed statistically using the independent sample t-test. The results of the analysis of the independent sample t-test obtained the p = 0.002 therefore it can be concluded that there is a significant difference in the value of platelet aggregation in the rat group with a standard and high-fat diet

Item Type:	Thesis (Karya Tulis Ilmiah)
Uncontrolled Keywords:	platelet aggregation, wistar rats, high-fat diet
Subjects:	Q Science > Q Science (General) R Medicine > RS Pharmacy and materia medica
Depositing User:	USB
Date Deposited:	04 Mar 2024 02:11
Last Modified:	04 Mar 2024 02:11
URI:	http://repo.setiabudi.ac.id/id/eprint/6069

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