UJI AKTIVITAS ANTIJAMUR SEDIAAN MOUTHWASH EKSTRAK DAUN SIRSAK (Annona muricata L) TERHADAP Candida albicans

Ani, Renadwi Siti (2023) UJI AKTIVITAS ANTIJAMUR SEDIAAN MOUTHWASH EKSTRAK DAUN SIRSAK (Annona muricata L) TERHADAP Candida albicans. Skripsi thesis, Universitas Setia Budi.

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Abstract

INTISARI ANI, R.S., 2023, UJI AKTIVITAS ANTIJAMUR SEDIAAN MOUTHWASH EKSTRAK DAUN SIRSAK (Annona muricata Linn.) TERHADAP Candida albicans, SKRIPSI, FAKULTAS FARMASI, UNIVERSITAS SETIA BUDI, SURAKARTA Candida albicans dapat menginfeksi rongga mulut memiliki ciri khas bercak putih jika dikeruk meninggalkan permukaan merah dan berdarah pada lidah, gingiva dan membran mukosa disebut Candidiasis. Daun sirsak memiliki aktivitas antijamur. Humectan (gliserin) berfungsi mengurangi penguapan serta memperlama kontak dengan gigi pada sediaan mouthwash. Penelitian ini bertujuan untuk memformulasikan sediaan mouthwash dengan variasi konsentrasi gliserin ekstrak daun sirsak yang memiliki aktivitas antijamur terhadap Candida albicans. Ekstrak diperoleh dengan maserasi menggunakan etanol 96%. Formulasi mouthwash menggunakan konsentrasi 10% ekstrak daun sirsak (Annona muricata L) dengan variasi konsentrasi gliserin 10; 15; dan 20%. Kontrol positif menggunakan ketokonazol 2% dan kontrol negatif formula mouthwash tanpa ekstrak. Pengujian mutu fisik meliputi uji organoleptis, pH, viskositas dan stabilitas. Pengujian aktivitas antijamur dilakukan menggunakan metode difusi cakram. Data diolah dengan statistik Shapiro-Wilks dilanjutkan One Way ANOVA untuk mengetahui nilai signifikansi dari uji mutu fisik dan daya hambat suatu sediaan. Hasil keenam formulasi sediaan mouthwash dengan variasi konsentrasi gliserin 10; 15% memiliki mutu fisik dan stabilitas yang baik. Sediaan mouthwash ekstrak daun sirsak konsentrasi 10% dengan variasi konsentrasi gliserin 10; 15; 20% menghasilkan zona hambat berturut-turut sebesar 14,27 mm±0,02; 15,36 mm±0,42; dan 16,29mm±0,07 dengan kontrol positif sebesar 32,48mm±0,21. Aktivitas antijamur mouthwash masih termasuk dalam kategori kuat. ABSTRACT ANI, S.A., 2023, TEST ACTIVITIES OF ANTIFUNGAL MOUTHWASH SOURSOP LEAF EXTRACT (Annona muricata Lin.) ON Candida albicans, SKRIPSI, FACULTY OF PHARMACEUTICAL, UNIVERSITY SURAKARTA SETIA BUDI Candida albicans can infect the oral cavity characterized by white patches if scraped leaving a red and bleeding surface on the tongue, gingiva and mucous membrane called Candidiasis. Soursop leaves have antifungal activity. Humectants (glycerin) function to reduce evaporation and prolong contact with the teeth in mouthwash preparations. This study aims to formulate mouthwash preparations with varying concentrations of glycerin from soursop leaf extract which has antifungal activity against Candida albicans. The extract was obtained by maceration using 96% ethanol. The formulation was made of extract concentration 10% was used which was the most effective and variations in the concentrations of glycerin such as 10%; 15%; and 20%. The positive control used ketoconazole 2% and negative control using mouthwash without soursop leaf extract.Physical quality testing includes organoleptic, Ph, viscosity, stability. The antifungal activity was tested out using the disc diffusion method. The data was processed using Shapiro-Wilks statistics followed by One Way ANOVA. The results of the six mouthwash with variations in concentration of 10; and 15% formulations had good physical quality and stability. Mouthwash preparation with 10% concentrations with variations of 10; 15; and 20% glycerin resulted in an inhibition zone of 14,27 mm±0,02 respectively; 15,36 mm±0,42; dan 16,29mm±0,07 with a positive control of 32,48mm±0,21 (p˂0,05) but the antifungal activity of the extract was still included in the strong category

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Annona muricata L.; mouthwash; gliserin; Candida albicans
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	USB
Date Deposited:	06 Mar 2024 01:33
Last Modified:	06 Mar 2024 01:33
URI:	http://repo.setiabudi.ac.id/id/eprint/6122

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