PENGARUH PEMBERIAN SALEP EKSTRAK DAUN JAMBU BIJI (Psidium guajava) TERHADAP LUKA BAKAR PADA KELINCI New Zealand

Qurani, Salsabilla Azky (2023) PENGARUH PEMBERIAN SALEP EKSTRAK DAUN JAMBU BIJI (Psidium guajava) TERHADAP LUKA BAKAR PADA KELINCI New Zealand. Skripsi thesis, Universitas Setia Budi.

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Abstract

INTISARI QURANI, S.A., 2022, PENGARUH PEMBERIAN SALEP EKSTRAK DAUN JAMBU BIJI (Psidium guajava) TERHADAP LUKA BAKAR PADA KELINCI NEW ZEALAND, SKRIPSI, FAKULTAS FARMASI, UNIVERSITAS SETIA BUDI, SURAKARTA. Penanganan luka bakar dengan komponen herbal merupakan cara yang aman untuk mengatasi luka bakar, salah satunya dengan menggunakan ekstrak daun jambu biji. Daun jambu biji mengandung senyawa tanin untuk meningkatkan penyembuhan luka melalui berbagai mekanisme, khususnya menangkal radikal bebas dan oksigen reaktif, meningkatkan penyembuhan luka dan meningkatkan pembentukan kapiler dan fibroblas. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pemberian ekstrak daun jambu biji terhadap penyembuhan luka bakar pada kelinci. Ekstraksi pada penelitian ini memanfaatkan metode maserasi. Diformulasikan dalam sediaan salep dengan kosentrasi 15%, 25% dan 35%. Sediaan diuji mutu fisiknya meliputi uji organoleptis, homogenitas, viskositas, daya sebar, daya lekat, pH dan stabilitas. Pengujian aktivitas luka bakar salep ekstrak daun jambu biji pada kelinci dilakukan 2 kali sehari dalam jangka waktu 21 hari. Data yang telah diperoleh akan di uji menggunakan uji normalitas, homogenitas, one-way ANOVA, dan uji post hoc Tukey HSD menggunakan SPSS. Pemberian salep ekstrak daun jambu biji (Psidium guajava linn.) kosentrasi 15%, 25%, dan 35% memberikan efektifitas terhadap penyembuhan luka bakar. Hasil analisis statistik menunjukkan sediaan salep ekstrak daun jambu biji kosentrasi 25% menunjukkan efektifitas penyembuhan luka bakar serta tidak berbeda nyata dengan kontrol positif. Peningkatan kosentrasi sediaan salep ekstrak daun jambu biji menunjukkan peningkatan efektifitas penyembuhan luka bakar. ABSTRACT QURANI, S.A., 2022, THE EFFECT OF GIVING GUAVA LEAF EXTRACT OINTMENT (Psidium guajava) ON BURNS IN NEW ZEALAND RABBITS, THESIS, FACULTY OF PHARMACY, SETIA BUDI UNIVERSITY, SURAKARTA. Handling burns with herbal components is a safe way to overcome burns, one of which is by using guava leaf extract. Guava contains tannin compounds to promote wound healing through various mechanisms, in particular counteracting free radicals and reactive oxygen, promoting wound healing and enhancing the formation of capillaries and fibroblasts. The purpose of this study was to determine the effect of guava leaf extract on the healing of burns in rabbits. In this study, there were five treatment groups, namely group 1 concentration of guava leaf extract 15%, group 2 concentration of guava leaf extract 25%, concentration of guava leaf extract 35%, group 4 negative control of ointment base, and group 5 positive control of Mebo Testing the properties of ointments using organoleptic tests, homogeneity tests, viscosity tests, dispersion tests, adhesion tests, and pH tests. Testing the activity of guava leaf extract ointment in rabbits was carried out 2 times a day within a period of 21 days. The data obtained will be tested using normality, homogeneity, one-way ANOVA, and post hoc Tukey HSD tests using SPSS. Guava leaf extract (Psidium guajava linn.) in ointment preparations has good physical quality preparations. The test results against wounds on the back of rabbits showed that guava leaf extract ointment with a concentration of 15%, 25% and 35% has a burn healing effect. Guava leaf ointment is 25% effective as a burn healing.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Ekstrak Daun Jambu Biji, Penyembuhan Luka Bakar, Senyawa Tanin
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: USB
Date Deposited: 06 Mar 2024 02:09
Last Modified: 06 Mar 2024 02:09
URI: http://repo.setiabudi.ac.id/id/eprint/6129

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