FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN OBAT KUMUR EKSTRAK DAUN MIMBA (Azadirachta indica A. Juss) TERHADAP BAKTERI Streptococcus mutans ATCC 25175

Salsa Bila, Nabila (2024) FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN OBAT KUMUR EKSTRAK DAUN MIMBA (Azadirachta indica A. Juss) TERHADAP BAKTERI Streptococcus mutans ATCC 25175. Skripsi thesis, Universitas Setia Budi.

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Abstract

Obat kumur merupakan sediaan yang berbentuk cairan dan memiliki kandungan zat antibakteri. Daun mimba memiliki kandungan golongan senyawa berupa steroid/triterpenoid yang bermanfaat sebagai aktivitas antibakteri. Tujuan dari penelitian ini untuk mengetahui pengaruh variasi konsentrasi gliserin terhadap mutu fisik dan stabilitas sediaan obat kumur ekstrak daun mimba (Azadirachta indica A. Juss). Mengetahui efek antibakteri dan formula obat kumur ekstrak daun mimba yang paling efektif efek antibateri terhadap bakteri Streptococcus mutans. Penelitian ini menggunakan empat formula sediaan obat kumur ekstrak daun mimba (Azadirachta indica A. Juss) sebesar 1% dengan variasi konsentrasi gliserin sebesar F1 (12%), F2 (24%), F3 (30%) dan F- (k-) sediaan obat kumur tanpa ekstrak daun mimba dengan konstrasi gliserin sebesar 12% , serta kontrol (+) obat kumur dari pasaran “X”. Pengujian mutu fisik sediaan meliputi organoleptis, homogenitas, berat jenis, pH, viskositas, dan stabilitas sediaan (cycling test). Sediaan obat kumur diujikan terhadap bakteri Streptococcus mutans menggunakan metode difusi cakram kertas. Hasil penelitian menunjukkan bahwa sediaan obat kumur pada semua formula dengan mutu fisik organoplik, homogenitas, viskositas, pH, berat jenis dan stabilitas menghasilkan sediaan yang baik. Pada pengujian aktivitas antibakteri sediaan obat kumur didapatkan nilai diameter zona hambat yaitu F1 9,94 mm; F2 11,57 mm; F3 8,91 mm; F- (k-) 0 mm; dan kontrol positif 9,47 mm. Dari ketiga formula yang memiliki diameter zona hambat paling baik yaitu F2. Mouthwash is a preparation in liquid form and contains antibacterial substances. Neem leaves contain a class of compounds in the form of steroids/triterpenoids which are useful for antibacterial activity. The aim of this research was to determine the effect of variations in glycerin concentration on the physical quality and stability of neem leaf extract (Azadirachta indica A. Juss) mouthwash preparations. To find out the antibacterial effect and mouthwash formula of neem leaf extract which has the most effective antibacterial effect against Streptococcus mutans bacteria. This study used four mouthwash formulations of 1% neem leaf extract (Azadirachta indica A. Juss) with varying glycerin concentrations, namely preparations F1 (12%), F2 (24%), F3 (30%) and F- (k-). mouthwash without neem leaf extract with a glycerin concentration of 12%, as well as control mouthwash (+) from the market "X". Physical quality testing of preparations includes organoleptic, homogeneity, specific gravity, pH, viscosity and stability of preparations (cycle test). Mouthwash preparations were tested against Streptococcus mutans bacteria using the paper disc diffusion method. The research results showed that mouthwash preparations in all formulas with organoplastic physical quality, homogeneity, viscosity, pH, specific gravity and stability produced good preparations. In testing the antibacterial activity of mouthwash preparations, the diameter of the inhibition zone was F1 9.94 mm; F2 11.57mm; F3 8.91mm; F- (k-) 0 mm; and positive control 9.47 mm.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	daun mimba, sediaan obat kumur, Streptococcus mutans, mouthwash preparations, neem leaves.
Subjects:	Q Science > QR Microbiology R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	USB
Date Deposited:	26 Jun 2024 01:10
Last Modified:	26 Jun 2024 01:27
URI:	http://repo.setiabudi.ac.id/id/eprint/6263

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