UJI AKTIVITAS ANTI-AGING SEDIAAN EMULGEL EKSTRAK DAUN STROBERI (Fragaria x ananassa) PADA KULIT PUNGGUNG KELINCI NEW ZEALAND YANG DIPAPAR SINAR UV-A

Widnyani, Ni Ketut Simpen (2024) UJI AKTIVITAS ANTI-AGING SEDIAAN EMULGEL EKSTRAK DAUN STROBERI (Fragaria x ananassa) PADA KULIT PUNGGUNG KELINCI NEW ZEALAND YANG DIPAPAR SINAR UV-A. Skripsi thesis, Universitas Setia Budi.

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Abstract

Sinar UV-A yang terkandung dalam sinar matahari menyebabkan penuaan dini. Daun stroberi (Fragaria x ananassa) yang mengandung antioksidan dan tabir surya dapat mencegah penuaan dini dan diformulasikan menjadi sediaan topikal anti- aging. Penelitian ini bertujuan mengetahui variasi konsentrasi ekstrak daun stroberi sediaan emulgel yang dapat memberikan aktivitas anti-aging mutu fisik serta stabilitas yang baik menggunakan kelinci yang dipapar sinar UV-A. Ekstrak daun stroberi dibuat menggunakan metode maserasi dengan pelarut etanol 96%, kemudian diformulasikan menjadi sediaan emulgel. Uji aktivitas anti- aging menggunakan 3 ekor kelinci. Setiap hari punggung kelinci dioles sediaan emulgel ekstrak daun stroberi dengan variasi konsentrasi yaitu 0,25%; 0,5%; 1% kemudian dipapar sinar UV-A selama 6 jam dilakukan selama 30 hari. Pengamatan parameter persen kolagen, persen elastisitas, dan persen kelembapan dilakukan pada hari ke-0 dan hari ke-30 setelah diolesi dengan emulgel menggunakan skin analyzer. Hasil penelitian diolah secara statistic menggunakan SPSS. Variasi konsentrasi ekstrak daun stroberi pada emulgel mempengaruhi pH namun tidak mempengaruhi viskositas. Pengujian keamanan sediaan tidak mengiritasi. Konsentrasi pada uji aktivitas anti- aging terbaik adalah konsentrasi ekstrak daun stroberi sebesar 1%. UV-A rays contained in sunlight can cause premature aging. Strawberry leaves (Fragaria x ananassa) which contains antioxidants and sunscreen can prevent premature aging and is formulated into topical preparations anti-aging. This study aims to determine variations in the concentration of strawberry leaves in an emulgel preparation that can provide anti-aging activity, good in physical quality and stability using rabbits exposed by UV-A rays. Strawberry leaves extract was made using the maceration metod with 96% etanol solvent, then formulated into an emulgel preparation. Activity test anti-aging using 3 rabbits. Every day the rabbit's back was smeared with an emulgel preparation of strawberry leaves extract with concentration variations, i.e. 0.25%; 0.5%; 1% was then exposed to UV-A rays 6 hours for 30 days. The parameters of % collagen, % elasticity, and % moisture were observed on day 0 and day 30 after being smeared emulgel using skin analyzer. The research results were processed statistically using SPSS Variation in the concentration of strawberry leaves extract in the emulgel affect the pH but don’t affect the viscosity. The safety test of the preparation is non- irritating. The best anti-aging activity test concentration is 1% strawberry leaf extract concentration.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	anti-aging, ekstrak daun stroberi, emulgel, skin analyzer, strawberry leaves extract.
Subjects:	Q Science > Q Science (General) Q Science > QR Microbiology
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	USB
Date Deposited:	26 Jun 2024 02:06
Last Modified:	26 Jun 2024 02:06
URI:	http://repo.setiabudi.ac.id/id/eprint/6267

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