ANTIARTHRITIS AND ANTI-INFLAMMATORY ACTIVITY OF Acalypha indica L. HERBS ON RATS

Herowati, Rina and KOLOBANI, MATIAS NATANIEL and KLAU, Maria Happy Chistian and Widodo, Gunawan Pamuji (2017) ANTIARTHRITIS AND ANTI-INFLAMMATORY ACTIVITY OF Acalypha indica L. HERBS ON RATS. In: ICPPS, 2017. (Submitted)

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Abstract

Acalypha indica L. has been used as traditional medicine in arthritis therapy due to its anti-inflammatory activity. This research investigated the antiarthritis as well as anti- inflammatory activity of A. indicia herbs extract and fractions. Arthritis model rats were induced by 0.2 ml intraplantar Collagen Freund Adjuvant. Ethanol extract of A. indica herbs doses of 50, 100 and 200 mg/kg daily were administered for 18 days. The paw volume was recorded using plesthymometer every 3 days. The extract then was fractionated by vacuum liquid chromatography, resulted 5 fractions. Anti-inflammatory test by carrageenan-induced rat paw oedema method, membrane stabilization test as well as protein denaturation inhibition test were conducted on these 5 fractions. Anti-arthritis activity test showed that the A. indica ethanol extract dose of 200 mg/kg bw reduced oedema volume and enhanced histopathological profile comparable to triamcinolone. Anti-inflammatory test showed that anti-inflammatory effect of fraction B was comparable to Diclofenac Na. Fraction B also showed highest membrane stabilization and protein denaturation inihibition activites among other fractions. The chemical compounds in fraction B were triterpenoids and steroids, based on the thin layer chromatography profile.

Item Type: Conference or Workshop Item (Speech)
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S2 Farmasi
Depositing User: rina herowati
Date Deposited: 24 Aug 2024 04:53
Last Modified: 24 Aug 2024 04:53
URI: http://repo.setiabudi.ac.id/id/eprint/6303

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