OPTIMASI FORMULA TABLET BUKAL BILAYER MELOKSIKAM MENGGUNAKAN MATRIKS NATRIUM ALGINAT DAN HPMC K4M SERTA NATRIUM LAURIL SULFAT SEBAGAI ENHANCER

Falahi, Asa (2016) OPTIMASI FORMULA TABLET BUKAL BILAYER MELOKSIKAM MENGGUNAKAN MATRIKS NATRIUM ALGINAT DAN HPMC K4M SERTA NATRIUM LAURIL SULFAT SEBAGAI ENHANCER. Tesis thesis, Universitas Setia Budi Surakarta.

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Abstract

Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) that works as a selective inhibitor of cyclooxygenase-2 (COX-2) activity that has analgesic and anti-inflammatory that is widely used in the treatment of arthritis, osteoarthritis, joint disease and other oral surgery cases. This research aims to create a bilayer mucoadhesive buccal tablet dosage meloxicam which serves as a maintenance dose after intravenous use with a mixture of HPMC K4M, sodium alginate, sodium lauryl sulfate; determine the effect of varying the amount of polymer on the physical properties and drug release, as well as assess the ability of meloxicam permeation of the optimized formulation. The determination of formulas with 23 factorial design used Design Expert® as 8 formula. Tablets were prepared by direct compression method. The first layer which adheres to mucosa and containing of mucoadhesive polymers and drug. The second layer as backing membran and contain water impermeable agent. Tablets were subjected for physicochemical characterization test such as thickness, hardness, swelling, mucoadhesive strength, content uniformity, physical stability in simulated saliva, pH, in vitro drug release. Optimized buccal mucoadhesive bilayered tablet formulation were subjected for in vitro drug permeation through sheep buccal mucosa on 4 hour. The test results showed that sodium alginate and sodium lauryl sulphate significant increases swelling index and strength of attachment. HPMC significantly decrease the swelling index. Sodium alginate, sodium lauryl sulfate and HPMC significant increases the strength of attachment. Sodium alginate significantly increase drug release, HPMC and sodium lauryl sulfate significantly decreased the release of the drug. Number of meloxicam which is transported by 17.45 ± 0.57% for 4 hours, lag time 0.3 hours; 950.33 flux μg.cm-2.jam-1. Key: meloxicam, buccal bilayer, HPMC, natrium alginate, permeation

Item Type:	Thesis (Tesis)
Uncontrolled Keywords:	Key: meloxicam, buccal bilayer, HPMC, natrium alginate, permeation
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Prodi S2 Farmasi
Depositing User:	Herera Gadys USB
Date Deposited:	23 Feb 2019 03:01
Last Modified:	18 Sep 2020 03:47
URI:	http://repo.setiabudi.ac.id/id/eprint/644

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