Pratama, Rama (2023) NETWORK PHARMACOLOGY TANAMAN SELEDRI (Apium graveolens L.) DAN TANAMAN LADA HITAM (Piper nigrum L.) TERHADAP ARTRITIS REUMATOID. Skripsi thesis, Universitas Setia Budi.
![[img]](http://repo.setiabudi.ac.id/style/images/fileicons/text.png) |
Text
rama surat 22 22 nov.pdf Download (39kB) |
|
Text
form publikasi rama.pdf Download (1MB) |
|
Text
COVER - BAB 1.pdf Download (2MB) |
|
Text
BAB 2.pdf Download (642kB) |
|
Text
BAB 3.pdf Download (57kB) |
|
Text
BAB 4.pdf Restricted to Repository staff only Download (1MB) |
|
Text
BAB 5.pdf Restricted to Repository staff only Download (23kB) |
|
Text
DAFTAR PUSTAKA.pdf Download (197kB) |
|
Text
LAMPIRAN.pdf Restricted to Repository staff only Download (326kB) |
Abstract
RAMA PRATAMA, 2023, NETWORK PHARMACOLOGY OF CELERY (Apium graveolens L.) AND BLACK PEPPER (Piper nigrum L.) AGAINST RHEUMATOID ARTHRITIS, THESIS PROPOSAL, PHARMACY UNDERGRADUATE PROGRAM, FACULTY OF PHARMACY, SETIA BUDI UNIVERSITY, SURAKARTA. Supervised by Dr. apt. Rina Herowati, M.Si. and apt. Fransiska Leviana, S. Farm., M.Sc.. Rheumatoid arthritis is an autoimmune disease that attacks the joints, causing chronic inflammation, and can progress to a systemic autoimmune disease. At the cellular level, an inappropriate immune response leads to attacks on the synovium and bone. Celery and black pepper are believed to have the potential to reduce inflammatory symptoms. This study aims to identify and predict target proteins involved in the pathophysiology of rheumatoid arthritis. The research method uses network pharmacology. Data on celery and black pepper plant compounds were collected through KNApSAcK and literature. biological activity compounds are screened against target proteins using PubChem. Target proteins in the pathophysiology of rheumatoid arthritis were identified through KEGG pathway and literature. Validation of gene names was done with Uniprot. Identification of target protein and gene protein interactions using String. Prediction of target proteins from compound biological activity using Swiss Target Prediction, SuperPred, and SEA. Visualization of network pharmacology of compound-protein and protein-protein interactions was performed using Cytoscape. The network pharmacology visualization showed that the target proteins BTK, FOXP3, IL1B, IL2, IL4, IL17A, JUN, LAT, LCK, GATA3, SYK, and TNF were predicted to be the target of action of celery compounds such as apiin, apigenin, kaempferol, ferulic acid, isoquercetin, luteolin, p-coummaric acid, and quercetin; whereas black pepper compounds such as beta-sitosterol, caryophylene, chavicine, gallic acid, piperine, and tyramine interact to form network pharmacology profiles with predicted target proteins involved in the pathophysiologic pathway of rheumatoid arthritis.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | rheumatoid arthritis, celery, black pepper, network pharmacology, cytoscape.artritis reumatoid, seledri, lada hitam, network pharmacology, cytoscape |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | USB |
| Date Deposited: | 17 Oct 2024 05:36 |
| Last Modified: | 17 Oct 2024 05:36 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/6453 |
Actions (login required)
 |
View Item |
