“UJI EFEKTIVITAS ANTIDIARE EKSTRAK ETANOL DAUN BAYAM DURI (Amaranthus spinosus L.) TERHADAP TIKUS PUTIH JANTAN DENGAN METODE TRANSIT INTESTINAL”

Sari, Aulia Meyra Tristania (2024) “UJI EFEKTIVITAS ANTIDIARE EKSTRAK ETANOL DAUN BAYAM DURI (Amaranthus spinosus L.) TERHADAP TIKUS PUTIH JANTAN DENGAN METODE TRANSIT INTESTINAL”. Skripsi thesis, Universitas Setia Budi.

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Abstract

AULIA MEYRA TRISTANIA SARI. 2024. ANTIDIARRHEA EFFECTIVENESS TEST OF ETHANOL EXTRACT OF SPINACH LEAVES (Amaranthus spinosus L.) AGAINST MALE WHITE RATS USING INTESTINAL TRANSIT METHOD, THESIS, BACHELOR OF PHARMACY, FACULTY OF PHARMACY, UNIVERSITAS SETIA BUDI, SURAKARTA. Supervised by Dr. apt. Opstaria Saptarini, M.Si. and apt. Yane Dila Keswara, M.Sc. Spinach leaves contain secondary metabolites including tannins, flavonoids, alkaloids, saponins, and steroids/triterpenoids which have potential as antidiarrheals. Diarrhea is a condition where the frequency of defecation is more than normal with a watery consistency. The purpose of this study was to determine the effect and effective dose of spinach leaves extract as an antidiarrhea agent against male white rats induced by oleum ricini by the intestinal transit method. This research began with plant determination and continued with powder making, then extracted using the maceration method using 96% ethanol solvent. The antidiarrheal effectiveness test used the intestinal transit method and was induced with oleum ricini orally. As treatments, positive control (Loperamide HCL), negative control (CMC-Na 1%) and ethanol extract of spinach leaves at a dose of 200 were used; 300; 600 (mg/200g rat body weight). The parameter observed was the ratio of the distance traveled by the marker (norit) to the total length of the intestine. The smaller the ratio, the better the antidiarrheal effect produced. The results were analyzed statistically using normality and homogeneity tests followed by the One Way Anova method and Tukey's Post Hoc Test. The test results showed that doses of 300 and 600 (mg/200g rat body weight) were not significantly different from the positive control group. Ethanol extract of thorn spinach leaves can provide antidiarrheal effects in male white rats. A dose of 300 mg/200 g body weight for mice is an effective dose that can reduce the intestinal distance ratio value by 41,74%.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	antidiare, daun bayam duri, transit intestinal. antidiarrhea, spinach leaves, intestinal transit.
Subjects:	Q Science > Q Science (General) Q Science > QC Physics
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	USB
Date Deposited:	13 Nov 2024 03:04
Last Modified:	13 Nov 2024 03:04
URI:	http://repo.setiabudi.ac.id/id/eprint/6457

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