Hidayat, Rohman Riyan (2024) UJI AKTIVITAS ANTIDIARE EKSTRAK ETANOL DAUN NANGKA (Artocarpus heterophyllus) DARI BEBERAPA TEMPAT TUMBUH PADA MENCIT JANTAN. Skripsi thesis, Universitas Setia Budi.
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Abstract
ROHMAN RIYAN HIDAYAT, 2023, TEST OF ANTIDIARARE ACTIVITY OF ETHANOL EXTRACT OF JACKPOA LEAVES (Artocarpus heterophyllus) FROM SEVERAL PLACE OF GROWING ON MALE MICE, THESIS. BACHELOR OF PHARMACY STUDY PROGRAM. SETIA BUDI UNIVERSITY SURAKARTA. Supervised by Dr. apt. Titik Sunarni, S.Si., M.Sc. and apt. Santi Dwi Astuti, S. Farm. M.Sc. Diarrhea is a change that occurs in an increase in volume, dilution and frequency with or without blood mucus in stool that is not normal. Samples were obtained from Madiun (lowlands), Wonogiri (medium plains), and Karanganyar (highlands). Jackfruit leaves (Artocarpus heterophyllus) contain flavonoids, saponins, tannins, alkaloids, phenols and steroids. The flavonoid and tannin compounds in jackfruit leaves can shrink mucous membranes so they can suppress diarrhea. This study aims to determine which areas of jackfruit leaves are good for reducing antidiarrheal activity in male Swiss Webster strain mice. Jackfruit extract was extracted using the maceration method using 70% ethanol solvent. The antidiarrheal activity test was carried out by inducing oleum ricini orally at 0.5 ml/20 gBW of mice. This study was divided into 6 groups, namely normal control, negative control, positive control, Madiun area extract at a dose of 500 mg/KgBW, Wonogiri area extract at a dose of 500 mg/KgBW, Karanganyar area extract at a dose of 500 mg/KgBW. Antidiarrheal activity is carried out orally and observations are made on the onset of diarrhea, stool weight, frequency of diarrhea, and duration of diarrhea. Analysis of the data obtained was processed using One-way ANOVA statistics with the Statistical Product and Service Solution (SPSS) program. The results of research testing the antidiarrheal activity of ethanol extract of jackfruit leaves from the Madiun, Wonogiri and Karanganyar areas at a dose of 500 mg/KgBW can provide an antidiarrheal effect on male mice. Based on test results, administering ethanol extract of jackfruit leaves from the Madiun area at a dose of 500 mg/KgBW provided the best antidiarrheal activity in male Swiss Webster strain mice. ROHMAN RIYAN HIDAYAT, 2023, UJI AKTIVITAS ANTIDIARE EKSTRAK ETANOL DAUN NANGKA (Artocarpus heterophyllus) DARI BEBERAPA TEMPAT TUMBUH PADA MENCIT JANTAN, SKRIPSI. PROGRAM STUDI S1 FARMASI. UNIVERSITAS SETIA BUDI SURAKARTA. Dibimbing Oleh Dr. apt. Titik Sunarni, S.Si., M.Si. dan apt. Santi Dwi Astuti, S. Farm. M.Sc. Diare merupakan perubahan yang terjadi pada peningkatan volume, keenceran, dan frekuensi dengan atau tanpa lendir darah pada pengeluaran tinja yang tidak seperti biasanya. Sampel didapatkan dari daerah Madiun (dataran rendah), Wonogiri (dataran medium), dan Karanganyar (dataran tinggi). Daun nangka (Artocarpus heterophyllus) mengandung senyawa flavonoid, saponin, tanin, alkaloid, fenol, dan steroid. Senyawa flavonoid dan tanin pada daun nangka dapat menciutkan selaput lendir sehingga dapat menekan terjadinya diare. Penelitian ini bertujuan untuk mengetahui daerah daun nangka yang baik terhadap penurunan aktivitas antidiare pada mencit jantan galur swiss Webster. Ekstrak nangka diekstraksi dengan metode maserasi menggunakan pelarut etanol 70%. Uji aktivitas antidiare dilakukan dengan menginduksi oleum ricini secara oral sebanyak 0,5 ml/20 gBB mencit. Penelitian ini dibagi 6 kelompok yaitu kontrol normal, kontrol negatif, kontrol positif, ekstrak daerah Madiun dosis 500 mg/KgBB, ekstrak daerah Wonogiri dosis 500 mg/KgBB, ekstrak daerah Karanganyar dosis 500 mg/KgBB. Aktivitas antidiare dilakukan secara oral dan dilakukan pengamatan terhadap onset diare, bobot feses, frekuensi diare, dan lama terjadinya diare. Analisis data yang diperoleh diolah menggunakan statistik One-way ANOVA dengan program Statistical Product and Service Solution (SPSS). Hasil penelitian terhadap pengujian aktivitas antidiare ekstrak etanol daun nangka dari daerah Madiun, Wonogiri, dan Karanganyar dengan dosis 500 mg/KgBB dapat memberikan efek antidiare terhadap mencit jantan. Berdasarkan hasil pengujian pemberian ekstrak etanol daun nangka dari daerah Madiun dosis 500 mg/KgBB memberikan aktivitas antidiare yang paling baik pada mencit jantan galur swiss Webster.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | antidiare, daun nangka, oleum ricini, SPSS antidiarrheal, jackfruit leaves, oleum ricini, SPSS |
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | USB |
| Date Deposited: | 18 Nov 2024 03:12 |
| Last Modified: | 18 Nov 2024 03:12 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/6529 |
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