Nabila, Munanisa Rifda (2025) KAJIAN INTERAKSI OBAT PADA PASIEN DIABETES MELITUS TIPE 2 RAWAT INAP DI RSUD DR. SOEHADI PRIJONEGORO SRAGEN TAHUN 2023. Skripsi thesis, Universitas Setia Budi.
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Abstract
MUNANISA R.N., 2025, KAJIAN INTERAKSI OBAT PADA PASIEN DIABETES MELITUS TIPE 2 RAWAT INAP DI RSUD DR. SOEHADI PRIJONEGORO SRAGEN TAHUN 2023. SKRIPSI, PROGRAM STUDI S1 FARMASI, UNIVERSITAS SETIA BUDI, SURAKARTA, Dibimbing oleh Dr. apt. Jason Merari Peranginangin, M.Si., M.M dan apt. Dra. Pudiastuti RSP, M.M. Interaksi obat dapat terjadi ketika penggunaan kombinasi 2 atau lebih obat untuk terapi farmakologis yang menimbulkan efek yang tidak diinginkan. Interaksi dapat berupa interaksi minor, moderate dan mayor. Menurut mekanismenya dapat berupa interaksi farmakokinetik dan farmakodinamik. Tujuan dari penelitian ini adalah untuk mengetahui gambaran penggunaan obat antidiabetes, mengetahui obat yang paling banyak menimbulkan interaksi dan mengidentifikasi interaksi obat yang digunakan pada pasien DM Tipe 2 di rawat inap RSUD dr. Soehadi Prijonegoro Sragen pada tahun 2023. Penelitian ini termasuk jenis penelitian deskriptif yang bersifat non eksperimental dengan menggunakan data retrospektif. Sampel yang digunakan adalah pasien DM Tipe 2 di rawat inap RSUD dr. Soehadi Prijonegoro Sragen pada tahun 2023 sebanyak 100 orang. Selanjutnya, data rekam medis yang sudah didapat dianalisis secara deskriptif dan diidentifikasi tingkat keparahan serta mekanisme interaksi obatnya menggunakan situs web Drugs.com dan Stockley’s Drugs Interactions. Hasil analisis menunjukkan terdapat 89 pasien berpotensi mengalami interaksi obat. Tingkat keparahan interaksi obat terbanyak yaitu tingkat keparahan moderate (81,1%) dengan mekanisme farmakodinamik (23,6%). Obat yang banyak berpotensi menimbulkan interaksi yaitu lansoprazole dan sucralfate (9,54%). MUNANISA R.N., 2025. STUDY OF DRUG INTERACTIONS IN INPATIENT PATIENTS WITH TYPE 2 DIABETES MELLITUS AT DR. SOEHADI PRIJONEGORO SRAGEN HOSPITAL, 2023. SKRIPSI, BACHELOR OF PHARMACY STUDY PROGRAM, SETIA BUDI UNIVERSITY, SURAKARTA, Supervised by Dr. apt. Jason Merari Peranginangin, M.Sc., M.M and apt. Dra. Pudiastuti RSP, M.M. Drug interactions can occur when a combination of 2 or more drugs is used for pharmacological therapy which causes undesirable effects. Interactions can be minor, moderate and major interactions. According to the mechanism, there can be pharmacokinetic and pharmacodynamic interactions. The aim of this research is to determine the description of the use of antidiabetic drugs, find out which drugs cause the most interactions and identify drug interactions used in Type 2 DM patients inpatients at RSUD dr. Soehadi Prijonegoro Sragen in 2023. This research is a type of descriptive research that is non experimental in nature using retrospective data. The samples used were Type 2 DM patients inpatients at RSUD dr. Soehadi Prijonegoro Sragen in 2023 as many as 100 people. Next, the medical record data that was obtained was analyzed descriptively and identified the severity and mechanism of drug interactions using the Drugs.com and Stockley's Drugs Interactions websites. The results of this study showed that there were 89 patients who had the potential to experience drug interactions. The highest level of severity of drug interactions is moderate severity (81.1%) with pharmacodynamic mechanisms (23.6%). Drugs that have the potential to cause interactions are lansoprazole and sucralfate (9.54%).
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Diabetes Melitus, Drugs.com, Interaksi obat, Stockley’s Drugs Interactions Drug interactions, Diabetes Mellitus, Drugs.com, Stockley’s Drugs Interactions |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica R Medicine > RT Nursing |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | USB |
| Date Deposited: | 03 Jul 2025 07:10 |
| Last Modified: | 03 Jul 2025 07:10 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/6648 |
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