FORMULASI DAN UJI MUTU FISIK GEL NATRIUM DIKLOFENAK DENGAN VARIASI KONSENTRASI HPMC K15M DAN PROPILENGLIKOL

Sari, Lina Puspita (2017) FORMULASI DAN UJI MUTU FISIK GEL NATRIUM DIKLOFENAK DENGAN VARIASI KONSENTRASI HPMC K15M DAN PROPILENGLIKOL. Karya Tulis Ilmiah thesis, Universitas Setia Budi Surakarta.

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Abstract

Natrium dichlophenac is an anti-inflammation and analgesic agent, with such side effects as nausea, vomit, gastritis, and peptic ulcer. To reduce its side effects, the approach taken is to prepare topical preparation. This research employed HPMC K15M as gel base and propylenglycol as humectane. The use of HPMC and propylenglycol affects the physical quality of gel; therefore a study should be conducted on the effect of HPMC K15M and Propylenglycol variations that can produce the good physical quality of natrium dichlophenac gel. Natrium dichlophenac gel is made in 3 formulas with varying concentrations of HPMC K15M and Propylenglycol: 4%:10%; 5%:9%; 6%:8%. The test was conducted for 3 weeks on the physical quality of gel tested including organoleptic characteristic, viscosity, adhesiveness, spreadability, and pH. The data was analyzed using SPSS statistic version 17.0 program with one-way Anova and Independent T-test. The result of research showed that varying concentrations of HPMC K15M and propylenglycol affected the physical quality of natrium dichlophenac gel preparation including viscosity, spreadability, and adhesiveness, but not organoleptic characteristic, homogeneity and pH. The test results showed that natrium dichlophenac gel with varying concentrations of HPMC K15M 4% and propylenglycol 10% have a good physical quality for 3 weeks. Keywords: gel, natrium dichlophenac, HPMC K15M, propylenglycol

Item Type:	Thesis (Karya Tulis Ilmiah)
Uncontrolled Keywords:	gel, natrium dichlophenac, HPMC K15M, propylenglycol
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Prodi D3 Farmasi
Depositing User:	Rohma Tri Wardani
Date Deposited:	23 Feb 2019 03:23
Last Modified:	23 Feb 2019 03:23
URI:	http://repo.setiabudi.ac.id/id/eprint/669

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