SINTESIS SENYAWA 1-(2,4-DIHIDROKSI)-3- (3,4-DIMETOKSIFENIL)PROP-2-EN-1-ON

NIRWANI, Laksmiari Sekar (2018) SINTESIS SENYAWA 1-(2,4-DIHIDROKSI)-3- (3,4-DIMETOKSIFENIL)PROP-2-EN-1-ON. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Chalcones are considered as the precursors of flavonoids which consist of two aromatic rings linked by a three-carbon α,β-unsaturated carbonyl system. Chalcone and its analogues have been reported to possess various biological activities such as antibacterial, anticancer, antifungal, anti-inflammatory and antioxidant. The aim of this study was to synthesize 1-(2,4-dihydroxy)-3-(3,4dimethoxyphenyl)prop-2-en-1-one is a derivative of chalcone. The research was started by synthesizing 2,4-dihydroxyacethophenon through Friedel-Crafts acylation from resorsinol. Product of acethophenon was then reacted with 3,4-dimethoxybenzaldehyde in presence of NaOH 50% through Claisen-Schmidt condensation to collect 1-(2,4-dihydroxy)-3-(3,4dimethoxyphenyl)prop-2-en-1-on. Then the solid obtained was recrystalized using methanol. Thin layer and gas chromatography were used as purity test method. The structure of the compound was elucidated using mass spectrometer and infrared spectrophotometer. The results showed that product was succesfully synthesized. Yellowishorange solid was obtained from the first synthesis with 86,14% of yield and it was confirmed as 2,4-dihydroxyacetophenone. Yellow solid was collected from the second synthesis with 51,32% of yield. It was confirmed as 1-(2,4-dihydroxy)-3(3,4-dimethoxyphenyl)prop-2-en-1-one. Structure elucidation showed that the chemical structure was appropriate to estimated chemical structure. Keyword : 2,4-dihydroxyacetophenone; 3,4-dimethoxybenzaldehyde; chalcone

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: 2,4-dihydroxyacetophenone; 3,4-dimethoxybenzaldehyde; chalcone
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 23 Feb 2019 03:24
Last Modified: 23 Feb 2019 03:24
URI: http://repo.setiabudi.ac.id/id/eprint/685

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