AKTIVITAS ANTIHIPERGLIKEMIK, PENGHAMBATAN STRESS OKSIDATIF DAN REGENERASI SEL β PANKREAS FRAKSI-FRAKSI EKSTRAK ETANOL DAUN KELOR (Moringa oleifera Lamk.) PADA TIKUS YANG DIINDUKSI STREPTOZOTOZIN-NIKOTINAMID

Rame, Magi Melia Tanggu (2016) AKTIVITAS ANTIHIPERGLIKEMIK, PENGHAMBATAN STRESS OKSIDATIF DAN REGENERASI SEL β PANKREAS FRAKSI-FRAKSI EKSTRAK ETANOL DAUN KELOR (Moringa oleifera Lamk.) PADA TIKUS YANG DIINDUKSI STREPTOZOTOZIN-NIKOTINAMID. Tesis thesis, Universitas Setia Budi Surakarta.

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Abstract

In the pathological state such as diabetes mellitus, increased oxidative stress will cause decrease in endogenous antioxidant activity in the body so that the body do not able detoxify free radical and prevent cell damage. One source of natural antioxidant as antidiabetic is Moringa oleifera leave. The purpose of this study was determine antihyperglycemic activity and antioxidant activity of SOD and GPx enzyme and decrease MDA level of Moringa oleifera leave ethanol extract and fractions of Moringa oleifera leave ethanol extract. This study was an laboratory experimental research using a post-test only group design. The subject of this study were 50 male Wistar rats which conditioned type 2 diabetes by streptozotozin-nicotinamid induction. Rats were randomly divided into 10 groups, and each group consisted of 5 rats. Doses of ethanol extract fractions of Moringa leaves were used the fraction of n-hexane 32 mg/kg of rats body weight and 64 mg/kg rats body weight, the ethyl acetate fraction of 7.16 mg/kg rats body weight and 14 mg/kg rats body weight, the water fraction of 61 mg / kg rats body weight and 122 mg / kg rats body weight. The test results were showed that (1) the ethanol extract and fractions of ethanol extract of moringa leaves have antihyperglycemicactivity to the streptozotosin-nicotinamide-induced rats; (2) The ethanol extract and fractions of ethanol extract of moringa leaves can increase the activity of antioxidant enzymes of SOD, GPx and lower MDA levels; and (3) The ethanol extract and fractions of ethanol extract of moringa leaves increased the diameter of islet of langerhans and increase the population of the islet cells insulin production islet of langerhans. Keywords: moringa (Moringa oleifera Lamk.), antihyperglycemic activity, inhibition of oxidative stress, and regeneration of β-pancreatic cells

Item Type:	Thesis (Tesis)
Uncontrolled Keywords:	Keywords: moringa (Moringa oleifera Lamk.), antihyperglycemic activity, inhibition of oxidative stress, and regeneration of β-pancreatic cells
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S2 Farmasi
Depositing User:	Herera Gadys USB
Date Deposited:	23 Feb 2019 03:24
Last Modified:	22 Sep 2020 04:19
URI:	http://repo.setiabudi.ac.id/id/eprint/691

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