FORMULASI TABLET HISAP ASAM MEFENAMAT DENGAN VARIASI KONSENTRASI MANITOL DAN AVICEL PH 101 SEBAGAI BAHAN PENGISI SECARA GRANULASI BASAH

Novitasari, Pipit (2017) FORMULASI TABLET HISAP ASAM MEFENAMAT DENGAN VARIASI KONSENTRASI MANITOL DAN AVICEL PH 101 SEBAGAI BAHAN PENGISI SECARA GRANULASI BASAH. Karya Tulis Ilmiah thesis, Universitas Setia Budi Surakarta.

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Abstract

A lozenge is mostly contained one or more medicines, like antiseptic, local anesthetic, antitussive, analgesic, and decongestant. Mefenamic acid is categorized as NSAID (nonsteroidal anti-inflammatory drug) analgesic, which is quite well-known for medical usage in a tablet form, but this mefenamic acid is not easily consumed for people that have problem in swallow things. A development of mefenamic acid in a lozenge form will make this NSID is practically consume. The purpose of this research is to find the best formula of mefenamic acid lozenge, with variation concentrations fillers of manitol and avicel pH 101. Wet granulation method is applied in making this lozenge. Granulation was made in three formulations, formula I manitol 25% and avicel pH 101 75%, formula II manitol 50% and avicel pH 101 50%, formula III manitol 75% and avicel pH 101 25%. The granule obtained was tested physical properties include: flow time, repose angle, and drying shrinkage. The tablet results which obtained was tested the physical properties of tablet include: weight uniformity, hardness, friability, taste response and dissolve time test. The data obtained were analyzed statistically using ANOVA test. The result of this research shows that variation concentrations fillers of manitol and avicel pH 101 affects the physical characteristic of the mefenamic acid lozenge. Mefenamic acid lozenge with concentration of manitol 25%: avicel pH 101 75% was the best formula. Keywords: Mefenamic acid, lozenge, manitol, avicel pH 101

Item Type: Thesis (Karya Tulis Ilmiah)
Uncontrolled Keywords: Mefenamic acid, lozenge, manitol, avicel pH 101
Subjects: R Medicine > R Medicine (General)
Divisions: Fakultas Farmasi > Prodi D3 Farmasi
Depositing User: Rohma Tri Wardani
Date Deposited: 23 Feb 2019 03:25
Last Modified: 23 Feb 2019 03:25
URI: http://repo.setiabudi.ac.id/id/eprint/708

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