FORMULASI ORALLY DISINTEGRATING TABLET SALBUTAMOL SULFAT MENGGUNAKAN PENGISI F-MELT, PEMANIS XYLITOL DAN SUPERDISINTEGRANTS SISTEM EFFERVESCENT

Saputra, Sony Andika (2016) FORMULASI ORALLY DISINTEGRATING TABLET SALBUTAMOL SULFAT MENGGUNAKAN PENGISI F-MELT, PEMANIS XYLITOL DAN SUPERDISINTEGRANTS SISTEM EFFERVESCENT. Tesis thesis, Universitas Setia Budi Surakarta.

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Abstract

Salbutamol sulphate is a bronchodilator in the for asthma medication, which works selectively on the β2 adrenergic receptor. Orally disintegrating tablet formulation of salbutamol sulphate may improve the bioavailability of drugs. This research aims at optimizing and evaluating the effect of F-Melt, xylitol and effervescent with the wetting time, the tablet hardness, the friability, disintegration time and drug release in the fif minute of Orally Disintegrating tablets salbutamol sulphate. The simplex lattice design was applied to optimize Orally Disintegrating tablets salbutamol sulphate. Using variable F-Melt, xylitol and effervescent as independent variables. The countour determined the optimum area superimposed countour plot of hardness, wetting time, friability and drug were dissolved in 5 minutes using the Design Expert software. Results showed variable F-Melt may increase the duration of tablet wetness, tablet hardness, tablet friability and accelerate the disintegration time. Xylitol gaves effect to increase the wetting time, and the tablet hardness, reduce the friability, disintegration time and drug release. Effervescent affected and the improvement of wetting time, reduced tablet hardness, and the friability, disintegration time but accelerate speeding up the drug release. Interaction F-Melt and xylitol reduced wetting time, and accelerated the disintegration time and improved the quality of textures and flavors. Interaction xylitol and effervescent accelerated wetting time, reduced the friability, accelerated the disintegration time. The optimum formula obtained by a combination of F-Melt composition of 146.00 mg, 35.33 mg of xylitol and 13.65 mg effervescent system. Keywords: F-Melt, xylitol, effervescent, Orally Disintegrating tablets salbutamol sulphate

Item Type:	Thesis (Tesis)
Uncontrolled Keywords:	Keywords: F-Melt, xylitol, effervescent, Orally Disintegrating tablets salbutamol sulphate
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S2 Farmasi
Depositing User:	Herera Gadys USB
Date Deposited:	23 Feb 2019 03:29
Last Modified:	22 Sep 2020 04:23
URI:	http://repo.setiabudi.ac.id/id/eprint/721

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