OPTIMASI FORMULA TABLET BUK PIROKSIKAM KARBOPOL PROGRAM PASCASARJANA i IMASI BUKAL MUKOADHESIF DENGAN POLIMER KITOSAN DAN 940P, SERTA PENGHANCUR POLIETILEN GLIKOL (PEG 6000)

Puspitasary, Kiki (2017) OPTIMASI FORMULA TABLET BUK PIROKSIKAM KARBOPOL PROGRAM PASCASARJANA i IMASI BUKAL MUKOADHESIF DENGAN POLIMER KITOSAN DAN 940P, SERTA PENGHANCUR POLIETILEN GLIKOL (PEG 6000). Tesis thesis, Universitas Setia Budi Surakarta.

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Abstract

Piroxicam is one of the non steroidal anti inflammatory drug (NSAID) that acts as a cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) selective inhibitor that has analgesic, anti inflammatory activity widely used in the treatment of arthritis, osteoarthritis, other joint diseases and oral surgery cases. The aim of this research is to prepare mucoadhesive piroxicam buccal tablet having good physical quality with mixture of 940P carbopol, chitosan and crushing PEG 6000; to know the effect of variation on the number of polymers on physical properties and drug release.. Determination of the formula with simplex lattice design using Design Expert® software as much as 13 formulas. The preparation of buccal tablet formulas is made using dry granulation method. Test evaluation includes thickness, hardness, swelling index, bioadhesion strength, adhesion duration, uniformity of stock, physical stability in saliva simulation, surface pH, and drug release in vitro. The optimum formula tested the physical characteristics and compared with the predicted results of the Design Expert® software. The test results showed that kitosan and karbopol940P significantly increased the swelling index, PEG 6000 significantly lowered swelling index. Karbopol940P and kitosan significantly increased bioadhesion strength, PEG 6000 significantly decreases bioadhesion strength. PEG 6000 significantly increased drug release, karbopol940P and kitosan significantly decreased drug release. Keywords: piroxicam, buccal tablets, karbopol940P, kitosan, PEG 6000.

Item Type: Thesis (Tesis)
Uncontrolled Keywords: Keywords: piroxicam, buccal tablets, karbopol940P, kitosan, PEG 6000.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S2 Farmasi
Depositing User: Herera Gadys USB
Date Deposited: 23 Feb 2019 04:15
Last Modified: 22 Sep 2020 02:10
URI: http://repo.setiabudi.ac.id/id/eprint/808

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