AKTIVITAS FRAKSI-FRAKSI EKSTRAK ETANOL DAUN MURBEI (Morus australis Poir.) TERHADAP FUNGSI DAN HISTOLOGI HATI TIKUS PUTIH MODEL HIPERKOLESTEROLEMIA YANG DIBERI DIET TINGGI LEMAK

Huda, Nurul (2017) AKTIVITAS FRAKSI-FRAKSI EKSTRAK ETANOL DAUN MURBEI (Morus australis Poir.) TERHADAP FUNGSI DAN HISTOLOGI HATI TIKUS PUTIH MODEL HIPERKOLESTEROLEMIA YANG DIBERI DIET TINGGI LEMAK. Tesis thesis, Universitas Setia Budi Surakarta.

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Abstract

Mulberry leaves contains flavonoids, alkaloids, and polifenols.The purpose of this study is to know the activity of liver function based on ALT and AST level and to know the fraction effect of ethanol extract mulberry leaf to fatty liver by using cell degeneration parameter in the form of fatty liver (steatosis), inflammation and necrosis by doing Hematoxyin Eosin (HE) . Test animals used were male rats wistar strain as many as 35 rats divided into 7 groups, each group consisting of 5 rats. Group I as normal control, group II as a negative control, group III as a positive control (simvastatin 0,9 mg/kg BW), Group IV as extract ethanol dose 500 mg/kg BW, group V as fraction n-heksan dose 60 mg/kg BW, group VI as fraction ethyl acetate dose 40 mg/kg BW, group VI as fraction of water dose 400 mg/kg BW. All groups were given feed HFD+ PTU for 28 days except normal group were only given a standard feed. Giving the fraction of the test carried out for 2 weeks. The study result showed that fraction ethyl acetate dose 40 mg/kg BW was the optimum fraction in decreased ALT and AST levels in rats high-fat diet and PTU, and fraction ethyl acetate dose 40 mg/kg BW can protect liver from damage in rats fed high-fat diet based on histology image analysis. Keywords: Morus autralis Poir., ALT, AST, Liver histology

Item Type:	Thesis (Tesis)
Uncontrolled Keywords:	Keywords: Morus autralis Poir., ALT, AST, Liver histology
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S2 Farmasi
Depositing User:	Herera Gadys USB
Date Deposited:	23 Feb 2019 04:19
Last Modified:	23 Feb 2019 04:19
URI:	http://repo.setiabudi.ac.id/id/eprint/844

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