Oratmangun, Sandriani Alpius (2017) PENGARUH KOMBINASI FRAKSI ETIL ASETAT BUAH PARE (Momordica charantia L.) DAN FRAKSI ETIL ASETAT RIMPANG KUNYIT (Curcuma domestica Val.); TERHADAP FUNGSI HATI DAN GINJAL SERTA GAMBARAN HISTOPATOLOGI PADA TIKUS RESISTEN INSULIN. Tesis thesis, Universitas Setia Budi Surakarta.
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Abstract
Bitter melon fruit and turmeric is a plant that many common daily life and is widely used as a vegetable or a spice in cooking. This plant is known to be efficacious to treat diabetes mellitus. This study aims to determine the effect of a combination of ethyl acetate fraction of bitter melon fruit and turmeric on the liver and kidney function and description of histopathology in insulin resistance rat. This study was conducted using a completely randomized direction. The animals were divided into 8 groups that each group consisted of 5 rat: Group I as normal control rat were given equivalent amounts of Na-CMC 1%, group II as a negative control were g iven feed HFD, lard and fructose without treatment, III as a positive control group were given metformin 9 mg / 200 g BW group IV ethyl acetate fraction of turmeric 10mg / 200g BB, group V bitter melon fruit fraction of ethyl acetate 0.4 mg / 200 g B, group VI-VIII were each given ethyl acetate fraction bitter melon fruit: turmeric (0.8 mg: 5 mg; 0.4 mg: 10 mg and 0.2 mg: 20 mg). All groups were given feed-fructose HFD for 45 days except the normal group that was given the standard feed. Administration of consecutive the fraction was carried out for 15 days. The results showed that the ethyl acetate fraction of bitter melon fruit and turmeric (dose combination III) 0.2: 20mg / 200g BB can reduce levels of SGOT, SGPT, BUN and creatinine against liver and kidney function and can affect description of histopathology liver and kidney in insulin resistance rat. Keywords: Momordica charantia L., Curcuma domestica Val., SGPT, SGOT, BUN, Creatinine, High Fat Diet (HFD) induction.
| Item Type: | Thesis (Tesis) |
|---|---|
| Uncontrolled Keywords: | Keywords: Momordica charantia L., Curcuma domestica Val., SGPT, SGOT, BUN, Creatinine, High Fat Diet (HFD) induction. |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S2 Farmasi |
| Depositing User: | Herera Gadys USB |
| Date Deposited: | 23 Feb 2019 04:19 |
| Last Modified: | 18 Sep 2020 03:06 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/849 |
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