UJI TOKSISITAS SUBKRONIK MINYAK BIJI MAHONI (Swietenia macrophylla King.) TERHADAP KADAR AST DAN ALT SERTA GAMBARAN HISTOPATOLOGI ORGAN HATI PADA TIKUS PUTIH (Rattus norvegicus)

Astuty, Agusthina Tri (2017) UJI TOKSISITAS SUBKRONIK MINYAK BIJI MAHONI (Swietenia macrophylla King.) TERHADAP KADAR AST DAN ALT SERTA GAMBARAN HISTOPATOLOGI ORGAN HATI PADA TIKUS PUTIH (Rattus norvegicus). Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Mahogany seeds are commonly used as a traditional herb to treat diabetes mellitus. The research aims to evaluate the safety level of mahogany seeds oil as antihyperglicemic purpose and determine the toxic symptoms of mahogany seed oil towards the level of AST and ALT, also the image of liver histopathology in albino rat. This research used 50 male and 50 female rats that were divided into 5 group; 1 group of control and 4 treatment groups. The control group was treated by oral administration of aquadestilata and the treatment groups were treated by mahogany seeds oil at dose 300, 600, 900 mg/kg body weight (BW) and satellite group were treated with mahogany seeds oil 900 mg/kgBB. The oil and aquadestilata were given orally by using rat stomach tube in a single dose and was observated for 90 days and additional 28 days for satellite group to observe the reversible effect. The examination of AST and ALT was examined every 30 days of observation. The end of observation the animal was sacrificed for histopathology test. The result of this research revealed that mahogany seeds oil treatment increase the body weight of male rats in dose 300, 600 mg/kgBW and female rats in dose 900 mg/kgBW, also caused toxic symptoms showed as edema on female rats in dose 900 mg/kgBB. The seed oil of mahogany showed no effects on AST and ALT level, also in their liver histophatologycal image. Keywords: sub-chronic toxicity, mahogany seeds oil, the level of AST and ALT, liver histopathology

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	sub-chronic toxicity, mahogany seeds oil, the level of AST and ALT, liver histopathology
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Rohma Tri Wardani
Date Deposited:	23 Feb 2019 04:20
Last Modified:	23 Feb 2019 04:20
URI:	http://repo.setiabudi.ac.id/id/eprint/855

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