FORMULASI FAST DISINTEGRATING TABLETS KOMPLEKS INKLUSI KETOPROFEN DALAM β - SIKLODEKSTRIN DENGAN KOMBINASI SUPERDISINTEGRANT CROSPOVIDONE CLM DAN SODIUM STARCH GLYCOLATE

Wulan, Aikta (2017) FORMULASI FAST DISINTEGRATING TABLETS KOMPLEKS INKLUSI KETOPROFEN DALAM β - SIKLODEKSTRIN DENGAN KOMBINASI SUPERDISINTEGRANT CROSPOVIDONE CLM DAN SODIUM STARCH GLYCOLATE. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Ketoprofen is a nonsteroidal anti-inflammatory drugs that have low solubility in water which could result in a delay in the onset of drug action. Limitations of this compound can be resolved by making a drug delivery system that is capable of accelerating the disintegration and dissolution of the tablet as fast disintegrating tablets (FDT) and β-cyclodextrin inclusion complexes which can increase the solubility of ketoprofen. The purpose of this study is to determine the effect of the combination of crospovidone CLM and sodium starch glycolate in the physical and drug release and determine the ratio of concentration which resulted in rapid disintegration time and release desired. Ketoprofen inclusion complexes with β-cyclodextrin was made with a molar ratio of 1: 1 using the method of kneading. FDT was made by the method of direct compression. Crospovidon CLM and sodium starch glycolate used as independent variables. The resulting tablets were tested physical quality of the tablet mass, physical properties of the tablet, and drug release. results were compared statistically using analysis of variance (ANOVA, p-value = 0.05). The results showed that the combination of crospovidone CLM and sodium starch glycolate give effect on an increase in hardness, decreased friability, accelerate time wetting, accelerate disintegration in vitro and in vivo, and did not give effect on the drug release. The combination of crospovidone CLM at the highest concentration and sodium starch glycolate at the lowest concentration produces tablet with rapid disintegration time and drug release desired. Keywords : ketoprofen, β-cyclodextrin, inclusion complex, fast disintegrating tablets, crospovidone CLM, sodium starch glycolate.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	ketoprofen, β-cyclodextrin, inclusion complex, fast disintegrating tablets, crospovidone CLM, sodium starch glycolate.
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Rohma Tri Wardani
Date Deposited:	23 Feb 2019 04:20
Last Modified:	23 Feb 2019 04:20
URI:	http://repo.setiabudi.ac.id/id/eprint/856

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