PENGARUH EKSTRAK ETANOL BUAH BUNCIS (Phaseolus vulgaris L.) TERHADAP KADAR GLUKOSA DARAH DAN KADAR MALONDIALDEHID PADA TIKUS DIABETES YANG DIINDUKSI ALOKSAN

Normalisa, Normalisa (2018) PENGARUH EKSTRAK ETANOL BUAH BUNCIS (Phaseolus vulgaris L.) TERHADAP KADAR GLUKOSA DARAH DAN KADAR MALONDIALDEHID PADA TIKUS DIABETES YANG DIINDUKSI ALOKSAN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Degenerative diseases such as diabetes, increased oxidative stress in the body will cause an imbalance between antioxidant protective and increased free radical production. Phaseolus vulgaris one source of natural antioxidants as antidiabetic. The purpose of this study was to determine the activity of the ethanol extract of Phaseolus vulgaris as activity in lowering blood glucose levels and levels of malondialdehyde (MDA) and knowing the effective dose of extract Phaseolus vulgaris which is able to be equal to glibenclamide. This study was conducted using 30 male Wistar rats induced by alloxan single dose of 150 mg / kg bw intraperitoneally. Divided into six groups, each of 5 rats, group I: normal control, group II: negative control (0,5% CMC Na), group III: positive control using glibenclamide dose of 0,45 mg/kg bw, group IV, V and VI were treated with ethanol extract of Phaseolus vulgaris dose of 105 mg / kg bw, 210 mg / kg bw and 420 mg / kg bw respectively. Treatment was given for 14 days. Hypoglycaemic and antioxidant effects were evaluated using the parameters of blood glucose levels and malondialdehyde (MDA) level in rat liver. The results of this study showed that the ethanol extract of Phaseolus vulgaris can lower blood glucose levels of mice and MDA level. An effective dose comparable with glibenclamide in lowering blood glucose levels of mice and MDA levels is a dose of 420 mg / kg bw. Keywords : Phaseolus vulgaris, antihyperglycemic, malondiadehyde, antioxidant

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Phaseolus vulgaris, antihyperglycemic, malondiadehyde, antioxidant
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 23 Feb 2019 04:23
Last Modified: 23 Feb 2019 04:23
URI: http://repo.setiabudi.ac.id/id/eprint/901

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