Sagitafuri, Arintya Kumala (2017) FORMULASI TABLET CAMPURAN INTERAKTIF PREDNISON DENGAN OPTIMASI HOST PEMBAWA KOMBINASI AVICEL PH 101 DAN AMYLUM MANIHOT SECARA SIMPLEX LATTICE DESIGN DENGAN PENAMBAHAN SURFAKTAN NATRIUM LAURIL SULFAT. Skripsi thesis, Universitas Setia Budi Surakarta.
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Abstract
Prednison is the cure adverse inflammatory the a corticosteroid used to suppress the immune system and inflammatory made in the form of tablet small doses and difficult soluble in water and prednison having a process absorption slow in the body. Drug high-potential but having very low dose as prednison, system a mixture of interactive more profitable because guarantee of homogeneity, stability, and accelerating day the cure. The purpose of this research is to see the combined effect avicel PH 101 and amilum manihot bearing host and get a formula steady with the approach based on simplex optimize lattice design. A combination of avicel PH 101 and amilum in this research in the manufacture of tabletnya used method of direct compression, next optimize with the methods simplex a lattice of design variable the free avicel PH 101 and amilum manihot. The parameters of critical in this research was excruciating vulnerability, time in vitro was destroyed, Q30. A combination of the two components made three formula, the proportion of a formula first PH avicel 101 and amilum of 93,5 mg and 0 mg; a formula second amounting to 46,75 mg: 46,75 mg and formula used for third as much as 0 mg : 93,5 mg. Data analysis using one sample t-test . Combination avicel PH 101 and amilum manihotas a bearer host impact on the quality of physical tablet a mixture of interactive prednison. An increase in the proportion avicel PH 101 enhanced response to time were destroyed and an increase in the proportion amilum manihot to speed up the dissolution and vulnerability. After optimization obtained the optimum proportion of avicel PH 101 and amilum manihotat 98,1:1,9%. Keywords : A mixture of interactive, prednison micronized, avicel PH 101, amilum manihot, simplex lattice design.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | A mixture of interactive, prednison micronized, avicel PH 101, amilum manihot, simplex lattice design. |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Rohma Tri Wardani |
| Date Deposited: | 23 Feb 2019 04:23 |
| Last Modified: | 23 Feb 2019 04:23 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/907 |
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