UJI AKTIVITAS ANALGETIK DAN ANTIPIRETIK EKSTRAK BATANG YODIUM (Jatropha multifida L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR

Raka, Astrid Scendhia (2017) UJI AKTIVITAS ANALGETIK DAN ANTIPIRETIK EKSTRAK BATANG YODIUM (Jatropha multifida L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Yodium (Jatropha multifida L.) stem contains alkaloids and flavonoids which has potencies as analgetic and antipyretic. The aims of this study were to evaluate the analgetic and antipyretic effects of yodium stem extract in wistar white male rats. The subject of this study was 25 wistar white male rats (170-200 g; ±2-3 months) and yodium stem macerated with ethanol 96%. The rats were divided to 5 groups, they are negative group (CMC-Na), yodium stem extract 50 mg/kg, 100 mg/kg, 200 mg/kg, and positive group (paracetamol). Analgetic effect was evaluated using chemical induction method, acetic acid 1%, 0,3 ml/200 g rats was used to induce pain, then the stretched from the rats were recorded in 90 minutes. Antipyretic effect was evaluated using DTP vaccine 0,2 ml/200 g rats to induce fever. Analgetic data was analyzed using mann-whitney and Antipyretic effect was evaluated from temperature shift data which was analyzed using tamhane. The results of this study showed that yodium (Jatropha multifida L.) stem extract had analgetic and antipyretic effects in wistar white male rats. The most effective dose of yodium stem extract for analgetic and antipyretic was on 200 mg/kg. The analgetic effect of yodium stem extract 200 mg/kg was lower than paracetamol, whereas the antipyretic effect of yodium stem extract 200 mg/kg was same as paracetamol. Keyword : analgetic, antipyretic, yodium stem extract, Jatropha multifida L., paracetamol

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: analgetic, antipyretic, yodium stem extract, Jatropha multifida L., paracetamol
Subjects: R Medicine > R Medicine (General)
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Rohma Tri Wardani
Date Deposited: 23 Feb 2019 04:25
Last Modified: 23 Feb 2019 04:25
URI: http://repo.setiabudi.ac.id/id/eprint/926

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