FORMULASI DAN KARAKTERISASI SOLID LIPID NANOPARTICLES (SLN) LORATADIN

Zulistya, Ayunda Eka (2017) FORMULASI DAN KARAKTERISASI SOLID LIPID NANOPARTICLES (SLN) LORATADIN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Loratadine is an anthistamine “long acting” to reseptor H1 anthistaminic perifer. Loratadine belongs to class II of Biopharmaceutics Classification System (BCS), since it has poor water solubility and low dissolution rate, so it can be prepared Solid Lipid Nanoparticles (SLN) to improve drug solubility. The aim of this research is to know the loratadin can be made SLN preparation, the influence of combinations of lecithin and various types of tween (20/60/80) to the particle size, and the resulting SLN loratadin characterization. This research used combination of surfactants that is lecithin and various types of tween (20/60/80) and different GMS concentrations with a combination of solvent emulsification and sonication methods. The results showed that loratadine can be prepared by Solid Lipid Nanoparticles with a combination of solvent emulsification and sonication method, combination of surfactant lecithin and tween 80 yielding the smallest particle size, the entrapment efficiency of best formula was 69.11 ± 0.54% and 80.4 ± 0.99%. There was an increase in particle size after storage is 316,76 ± 15,36 (F2) and 377,26 ± 28,35 (F3), and the zeta potential value after storage was -15,44 ± 0,50 (F2) and -14 , 82 ± 0,51 (F3). Keywords: Loratadine, SLN, Emulsification, Sonication, Lecithin, Tween, GMS

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Loratadine, SLN, Emulsification, Sonication, Lecithin, Tween, GMS
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Rohma Tri Wardani
Date Deposited:	23 Feb 2019 04:26
Last Modified:	23 Feb 2019 04:26
URI:	http://repo.setiabudi.ac.id/id/eprint/941

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